MICB Antibody (9847-1): sc-80527
- MICB Antibody (9847-1) is a mouse monoclonal IgG2b, cited in 4 publications, provided at 100 µg/ml
- raised against the extracellular domain of MICB of human origin
- recommended for detection of MICB of human origin by WB and FCM
- See MICA/B (F-6): sc-137242 for MICB antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MICB Antibody (9847-1). This work is in progress.
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MICB Antibody (9847-1) is a mouse monoclonal IgG2b antibody that detects MICB in human samples through applications such as western blotting (WB) and flow cytometry (FCM). MICB, or MHC class I polypeptide-related sequence B, is a heavily glycosylated transmembrane protein that plays a crucial role in the immune response by serving as a stress-induced ligand for the NKG2-D receptor, which is present on natural killer cells, CD8+αβ T cells, and γδ T cells. This interaction is vital for activating the cytolytic response, thereby enhancing the host′s defense against virus-infected and tumor cells. Notably, MICB is predominantly expressed in epithelial cells, endothelial cells, and fibroblasts, where MICB functions to signal cellular distress and trigger immune responses, particularly in the intestinal epithelium. MICB shares a high degree of identity with MICA, with 91% sequence similarity, yet MICB is functionally distinct from conventional MHC class I molecules, as MICB does not require β-2-microglobulin for stability. The ability of MICB to evoke immune responses highlights MICB′s importance in maintaining immune surveillance and responding to cellular stress, making MICB a significant target for research in immunology and cancer therapy. Anti-MICB antibody (9847-1) is an essential tool for researchers aiming to explore the dynamics of immune responses and the role of stress-induced ligands in various pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MICB Antibody (9847-1) References:
- MICB Allele Genotyping on Microarrays by Improving the Specificity of Extension Primers. | Baek, IC., et al. 2015. PLoS One. 10: e0142467. PMID: 26569110
- MICA, MICB Polymorphisms and Linkage Disequilibrium with HLA-B in a Chinese Mongolian Population. | Wang, WY., et al. 2016. Scand J Immunol. 83: 456-62. PMID: 27028549
- MicroRNA-34a promotes MICB expression in hepatocytes. | Zhou, MT., et al. 2018. Carcinogenesis. 39: 1477-1487. PMID: 30256916
- Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. | Ferrari de Andrade, L., et al. 2020. Cancer Immunol Res. 8: 769-780. PMID: 32209637
- High MICB expression as a biomarker for good prognosis of colorectal cancer. | Feng, Q., et al. 2020. J Cancer Res Clin Oncol. 146: 1405-1413. PMID: 32306128
- Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis. | Wei, A., et al. 2023. J Pediatr Hematol Oncol. 45: e446-e454. PMID: 36898046
- Exploration of the role of NKG2D ligands MICA and MICB in JAK2 V617F-positive myeloproliferative neoplasms. | Ivanova, M., et al. 2023. HLA. 102: 168-178. PMID: 37002719
- MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death. | Aguilar, OA., et al. 2024. Am J Respir Crit Care Med. 209: 70-82. PMID: 37878820
- MICB Genetic Variants and Its Protein Soluble Level Are Associated with the Risk of Chronic GvHD and CMV Infection after Allogeneic HSCT. | Siemaszko, J., et al. 2024. Arch Immunol Ther Exp (Warsz). 72: PMID: 38847554
- The impact of MICB mismatches in unrelated haematopoietic stem cell transplantation. | Amann, EM., et al. 2024. HLA. 103: e15584. PMID: 38932717
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MICB Antibody (9847-1) | sc-80527 | 100 µg/ml | $322.00 |