MHC class II I E Antibody (C3A3-Do3): sc-59319

MHC class II I E Antibody (C3A3-Do3) is a mouse monoclonal IgG3 antibody that detects MHC class II I E protein of mouse and rat origin by western blotting (WB) and flow cytometry (FCM). Anti-MHC class II I E antibody (C3A3-Do3) is available as the non-conjugated format. MHC class II I E protein plays a crucial role in immune response by presenting processed exogenous antigens to CD4+ T lymphocytes, which are essential for orchestrating adaptive immunity. MHC class II I E protein is primarily located on the surface of antigen-presenting cells, such as dendritic cells, macrophages, and B cells, where MHC class II I E facilitates recognition of foreign peptides by T cells. The ability of MHC class II molecules to bind longer peptides, typically ranging from 13 to 18 amino acids, is vital for effective T cell activation and subsequent immune responses. Additionally, interaction of MHC class II I E with other proteins, such as HLA-DM and HLA-DO, is important for regulation of peptide loading and exchange, ensuring that immune system can respond appropriately to a diverse array of pathogens. The differential structural properties of MHC class II molecules, including unique peptide-binding grooves, underscore specialized function in immune surveillance and highlight importance of MHC class II I E in maintaining immune homeostasis.

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MHC class II I E Antibody (C3A3-Do3) References:

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