mGluR-8 Antibody (4A7): sc-517124
- mGluR-8 Antibody (4A7) is a mouse monoclonal IgG2a κ mGluR-8 antibody provided at 100 µg/ml
- raised against amino acids 486-575 representing partial length mGluR-8 of human origin
- recommended for detection of mGluR-8 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for mGluR-8 Antibody (4A7). This work is in progress.
mGluR-8 Antibody (4A7) is a mouse monoclonal IgG2a kappa light chain antibody that detects mGluR-8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-mGluR-8 antibody (4A7) is available as a non-conjugated format. mGluR-8, a member of the metabotropic glutamate receptor family, plays a crucial role in modulating synaptic transmission and plasticity in the central nervous system. mGluR-8 is primarily located in presynaptic terminals of neurons, where mGluR-8 regulates neurotransmitter release, influencing various physiological processes such as learning, memory, and anxiety. mGluR-8′s presynaptic positioning allows effective modulation of glutamate release in response to synaptic activity, contributing to fine-tuning of excitatory signaling in the brain. mGluR-8 interacts with specific G proteins that activate downstream signaling pathways, further emphasizing mGluR-8′s role in neurotransmission. Alternative splicing of this integral membrane protein results in three isoforms: a, b, and c, with human mGluR-8 mapping to q31.33 of chromosome 7.
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mGluR-8 Antibody (4A7) References:
- Cardiovascular responses to activation of metabotropic glutamate receptors in the nTS of the rat. | Viard, E. and Sapru, HN. 2002. Brain Res. 952: 308-21. PMID: 12376193
- AMPA receptor regulation mechanisms: future target for safer neuroprotective drugs. | Jayakar, SS. and Dikshit, M. 2004. Int J Neurosci. 114: 695-734. PMID: 15204061
- Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. | Takaki, H., et al. 2004. Am J Med Genet B Neuropsychiatr Genet. 128B: 6-14. PMID: 15211621
- Role of distinct NMDA receptor subtypes at central synapses. | Cull-Candy, SG. and Leszkiewicz, DN. 2004. Sci STKE. 2004: re16. PMID: 15494561
- Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception. | Marabese, I., et al. 2007. J Neurophysiol. 98: 43-53. PMID: 17507496
- Acute pharmacological modulation of mGluR8 reduces measures of anxiety. | Duvoisin, RM., et al. 2010. Behav Brain Res. 212: 168-73. PMID: 20385173
- mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. | Gosnell, HB., et al. 2011. Neuropsychopharmacology. 36: 1599-607. PMID: 21451497
- Group III mGluR8 negatively modulates TRPA1. | Govea, RM., et al. 2016. Neuroscience. 334: 134-147. PMID: 27497709
- Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4. | Gates, C., et al. 2018. Bioorg Med Chem. 26: 4797-4803. PMID: 30143366
- The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors. | Gates, CA., et al. 2023. Molecules. 28: PMID: 37836643
- Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. | Scherer, SW., et al. 1996. Genomics. 31: 230-3. PMID: 8824806
- The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1. | Scherer, SW., et al. 1997. Genomics. 44: 232-6. PMID: 9299241
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
mGluR-8 Antibody (4A7) | sc-517124 | 100 µg/ml | $322.00 |