MFG-E8 Antibody (SPM291): sc-56564
- MFG-E8 Antibody (SPM291) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against delipidated human milk fat globule membrane preparation
- recommended for detection of MFG-E8 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MFG-E8 Antibody (SPM291) for WB and IHC(P) applications. These reagents are now offered in bundles with MFG-E8 Antibody (SPM291) (see ordering information below).
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MFG-E8 Antibody (SPM291) is a mouse monoclonal IgG1 antibody that detects MFG-E8 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MFG-E8, also known as Milk fat globule-EGF factor 8 or Lactadherin, is a 387 amino acid peripheral membrane protein that plays a crucial role in cellular interactions and signaling. MFG-E8 is primarily located on the membranes of mammary epithelial cells and other tissues, where MFG-E8 serves as a specific ligand for Integrin β5 and Integrin β3. This interaction is vital for processes such as cell adhesion and migration, which are essential during fertilization and tissue repair. Furthermore, MFG-E8 has been shown to bind to rotavirus, inhibiting viral replication and thereby providing a protective mechanism against viral infections. The significance of MFG-E8 extends to breast cancer association, as MFG-E8 overexpression has been linked to tumorigenesis, highlighting potential use as a biomarker for cancer progression. With diverse functional roles and implications in health and disease, anti-MFG-E8 antibody (SPM291) is an invaluable tool for researchers studying cellular dynamics and cancer biology.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MFG-E8 Antibody (SPM291) References:
- Identification of MFG-E8 as a novel therapeutic target for diseases. | Li, BZ., et al. 2013. Expert Opin Ther Targets. 17: 1275-85. PMID: 23972256
- Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8. | Cheyuo, C., et al. 2019. Front Neurosci. 13: 569. PMID: 31213977
- Roles and mechanisms of MFG-E8 in vascular aging-related diseases. | Ni, YQ., et al. 2020. Ageing Res Rev. 64: 101176. PMID: 32971257
- MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells. | Cui, Y., et al. 2023. Cell Death Dis. 14: 2. PMID: 36596780
- MFG-E8 facilitates heart repair through M1/M2 polarization after myocardial infarction by inhibiting CaMKII. | Ding, P., et al. 2024. Int Immunopharmacol. 126: 111216. PMID: 37977072
- MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination. | Dong, X., et al. 2024. Neurosci Bull. 40: 483-499. PMID: 37979054
- Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells. | Luo, L., et al. 2023. J Nanobiotechnology. 21: 455. PMID: 38017428
- Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis. | Lin, S., et al. 2024. Gut. 73: 1110-1123. PMID: 38378253
- The regulation of MFG-E8 on the mitophagy in diabetic sarcopenia via the HSPA1L-Parkin pathway and the effect of D-pinitol. | Zhao, W., et al. 2024. J Cachexia Sarcopenia Muscle. 15: 934-948. PMID: 38553831
- Exploring the potential of MFG-E8 in neurodegenerative diseases. | Li, D., et al. 2024. Crit Rev Food Sci Nutr. 1-15. PMID: 39468823
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MFG-E8 Antibody (SPM291) | sc-56564 | 200 µg/ml | $316.00 | |||
MFG-E8 Antibody (SPM291): m-IgG Fc BP-HRP Bundle | sc-537102 | 200 µg Ab; 10 µg BP | $354.00 | |||
MFG-E8 Antibody (SPM291): m-IgGκ BP-HRP Bundle | sc-534294 | 200 µg Ab; 40 µg BP | $354.00 | |||
MFG-E8 Antibody (SPM291): m-IgG1 BP-HRP Bundle | sc-545004 | 200 µg Ab; 20 µg BP | $354.00 |