MetAP-2 Antibody (F-7): sc-365637
- MetAP-2 Antibody (F-7) is a mouse monoclonal IgG1 κ MetAP-2 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 152-183 within an internal region of MetAP-2 of human origin
- MetAP-2 Antibody (F-7) is recommended for detection of MetAP-2 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-MetAP-2 Antibody (F-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MetAP-2 Antibody (F-7) for WB and IHC(P) applications. These reagents are now offered in bundles with MetAP-2 Antibody (F-7) (see ordering information below).
MetAP-2 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects MetAP-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MetAP-2 (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Methionine aminopeptidases, such as MetAP-2, play a crucial role in protein maturation by removing N-terminal methionine residues from nascent peptides, a process essential for proper protein folding and function. This enzymatic activity is particularly important in eukaryotic cells, where MetAP-2 contributes to regulating cell proliferation and differentiation. MetAP-2′s conservation across species, including humans and Saccharomyces cerevisiae, highlights a fundamental role in cellular processes. Additionally, MetAP-2′s regulation by neurofibromin (NF1) and association with various cancers underscore potential as a therapeutic target; MetAP-2 inhibitors, such as ovalicin and fumagillin, have shown promise in cancer treatment by disrupting tumor proliferation linked to NF1 mutations.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MetAP-2 Antibody (F-7) References:
- Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model. | Chun, E., et al. 2005. Int J Cancer. 114: 124-30. PMID: 15523682
- Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models. | Morowitz, MJ., et al. 2005. Clin Cancer Res. 11: 2680-5. PMID: 15814649
- Methionine aminopeptidases type I and type II are essential to control cell proliferation. | Bernier, SG., et al. 2005. J Cell Biochem. 95: 1191-203. PMID: 15962312
- Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis. | Zhang, H., et al. 2005. Folia Parasitol (Praha). 52: 182-92. PMID: 16004378
- 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo. | Kallander, LS., et al. 2005. J Med Chem. 48: 5644-7. PMID: 16134930
- The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. | Sin, N., et al. 1997. Proc Natl Acad Sci U S A. 94: 6099-103. PMID: 9177176
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MetAP-2 Antibody (F-7) | sc-365637 | 200 µg/ml | $322.00 | |||
MetAP-2 Antibody (F-7): m-IgG Fc BP-HRP Bundle | sc-529419 | 200 µg Ab; 10 µg BP | $361.00 | |||
MetAP-2 Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-522305 | 200 µg Ab, 40 µg BP | $361.00 | |||
MetAP-2 Antibody (F-7): m-IgG1 BP-HRP Bundle | sc-543506 | 200 µg Ab; 20 µg BP | $361.00 | |||
MetAP-2 Antibody (F-7) AC | sc-365637 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MetAP-2 Antibody (F-7) HRP | sc-365637 HRP | 200 µg/ml | $322.00 | |||
MetAP-2 Antibody (F-7) FITC | sc-365637 FITC | 200 µg/ml | $336.00 | |||
MetAP-2 Antibody (F-7) PE | sc-365637 PE | 200 µg/ml | $349.00 | |||
MetAP-2 Antibody (F-7) Alexa Fluor® 488 | sc-365637 AF488 | 200 µg/ml | $364.00 | |||
MetAP-2 Antibody (F-7) Alexa Fluor® 546 | sc-365637 AF546 | 200 µg/ml | $364.00 | |||
MetAP-2 Antibody (F-7) Alexa Fluor® 594 | sc-365637 AF594 | 200 µg/ml | $364.00 | |||
MetAP-2 Antibody (F-7) Alexa Fluor® 647 | sc-365637 AF647 | 200 µg/ml | $364.00 | |||
MetAP-2 Antibody (F-7) Alexa Fluor® 680 | sc-365637 AF680 | 200 µg/ml | $364.00 | |||
MetAP-2 Antibody (F-7) Alexa Fluor® 790 | sc-365637 AF790 | 200 µg/ml | $364.00 | |||
MetAP-2 (F-7) Neutralizing Peptide | sc-365637 P | 100 µg/0.5 ml | $69.00 |