MetAP-2 Antibody (D-1): sc-365204

MetAP-2 Antibody (D-1) is a mouse monoclonal IgG2b antibody that detects MetAP-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MetAP-2, a member of the M24 family of proteins, plays a crucial role in removing N-terminal methionine residues from nascent peptides, a process essential for protein maturation and function. This enzymatic activity influences various cellular processes, including cell proliferation and differentiation. MetAP-2 is highly conserved across species, including humans and the yeast Saccharomyces cerevisiae, highlighting fundamental biological significance. Dysregulation of MetAP-2 has been implicated in several forms of cancer, with increased expression levels correlating with tumorigenesis, particularly in neurofibromatosis type 1 (NF1) associated tumors. The regulation of MetAP-2 by neurofibromin (NF1) underscores potential as a therapeutic target, as inhibitors like ovalicin and fumagillin, which bind to active sites, have shown promise in cancer treatment strategies. Anti-MetAP-2 antibody (D-1) enables researchers to gain valuable insights into MetAP-2′s role in various biological contexts and disease implications.

The preferred MetAP-2 antibody is MetAP-2 Antibody (F-7): sc-365637.