MEL-1A/B-R Antibody (B-8): sc-398788

MEL-1A/B-R Antibody (B-8) is a mouse monoclonal IgM antibody that detects MEL-1A/B-R in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MEL-1A/B-R antibody (B-8) is available in a non-conjugated form, allowing for versatile experimental use. MEL-1A-R and MEL-1B-R proteins function as G protein-coupled receptors that mediate physiological responses to melatonin, a hormone secreted by the pineal gland primarily at night. These receptors regulate circadian rhythms and play significant roles in reproductive development and tumorigenesis. The seven transmembrane domain structure enables interaction with melatonin and initiates intracellular signaling cascades, inhibiting adenylate cyclase and stimulating phospholipase Cb for downstream effects on cellular growth and function. Understanding MEL-1A-R and MEL-1B-R structure and function helps explain their roles in health and disease, particularly in circadian rhythm disorders and cancer.

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MEL-1A/B-R Antibody (B-8) References:

1. Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity.  |  Roka, F., et al. 1999. Mol Pharmacol. 56: 1014-24. PMID: 10531408
2. Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.  |  Brydon, L., et al. 1999. Mol Endocrinol. 13: 2025-38. PMID: 10598579
3. Melatonin receptors in human uveal melanocytes and melanoma cells.  |  Roberts, JE., et al. 2000. J Pineal Res. 28: 165-71. PMID: 10739303
4. Melatonin and mammary pathological growth.  |  Cos, S. and Sánchez-Barceló, EJ. 2000. Front Neuroendocrinol. 21: 133-70. PMID: 10764528
5. Melatonin and sex hormone interrelationships--a review.  |  Luboshitzky, R. and Lavie, P. 1999. J Pediatr Endocrinol Metab. 12: 355-62. PMID: 10821215
6. Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis.  |  Shiu, SY., et al. 2000. Biol Signals Recept. 9: 172-87. PMID: 10899702
7. Melatonin and biological rhythms.  |  Pévet, P. 2000. Biol Signals Recept. 9: 203-12. PMID: 10899705
8. Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits.  |  Haljas, K., et al. 2018. Ann Med. 50: 704-712. PMID: 30089436
9. Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction.  |  Chu, W., et al. 2022. Front Cell Dev Biol. 10: 954186. PMID: 36353509
10. Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus.  |  Wei, L., et al. 2023. J Zhejiang Univ Sci B. 24: 78-88. PMID: 36632752
11. Melatonin Receptor 1B and Corticosteroid Receptor Polymorphisms in Infertile Women with Implantation Failure and Miscarriages.  |  Robeva, R., et al. 2023. Front Biosci (Landmark Ed). 28: 122. PMID: 37395040
12. Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice.  |  Feng, Z., et al. 2024. Heliyon. 10: e38098. PMID: 39347399

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEL-1A/B-R Antibody (B-8) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-MEL-1A/B-R Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEL-1A/B-R Antibody (B-8) Specifications

Alternate Product Name: MEL-1A/B-R

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 161-280

Epitope Target: MEL-1A-R

Epitope Species: human

Product Reactivity/Detection: MEL-1A-R and MEL-1B-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for MEL-1A/B-R Antibody (B-8): N/A

The preferred MEL-1A-R antibody is MEL-1A-R Antibody (B-10): sc-390328.