mEH Antibody (17): sc-135984

mEH Antibody (17) is a mouse monoclonal IgG1 kappa light chain antibody that detects mEH protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-mEH antibody (17) is available as the non-conjugated form. mEH protein, also known as microsomal epoxide hydrolase, plays a crucial role in the detoxification of harmful compounds by catalyzing the hydrolysis of epoxides into less reactive and more water-soluble dihydrodiols, which can then be easily excreted from the body. This enzymatic process is vital for protecting cells from the potentially damaging effects of various endogenous and exogenous toxicants, including those derived from tobacco smoke. mEH protein is encoded by the EPHX1 gene, located on chromosome 1q42.12, and exhibits broad substrate specificity, allowing mEH protein to metabolize a wide range of substrates. Notably, polymorphisms in the EPHX1 gene have been associated with an increased risk of certain cancers, such as ovarian cancer and hepatocellular carcinoma, highlighting the importance of mEH in both metabolic processes and disease susceptibility.

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mEH Antibody (17) References:

1. Analysis of the EPHX1 113 polymorphism and GSTM1 homozygous null polymorphism and oral clefting associated with maternal smoking.  |  Hartsfield, JK., et al. 2001. Am J Med Genet. 102: 21-4. PMID: 11471167
2. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation.  |  Davis, BB., et al. 2002. Proc Natl Acad Sci U S A. 99: 2222-7. PMID: 11842228
3. Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer.  |  Lancaster, JM., et al. 1996. Mol Carcinog. 17: 160-2. PMID: 8944076
4. The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics.  |  Seidegård, J. and Ekström, G. 1997. Environ Health Perspect. 105 Suppl 4: 791-9. PMID: 9255563

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mEH Antibody (17) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-mEH Antibody (17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mEH Antibody (17) Specifications

Alternate Product Name: mEH

Product Clone Name: 17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 13-125

Epitope Target: mEH

Epitope Species: human

Product Reactivity/Detection: mEH

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for mEH Antibody (17): N/A