Med31 Antibody (3-9D): sc-101189

Med31 Antibody (3-9D) is a mouse monoclonal IgG2b kappa light chain antibody that detects Med31 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Med31 (3-9D) antibody is available as the non-conjugated anti-Med31 monoclonal isotype antibody. Med31, also known as mediator of RNA polymerase II transcription subunit 31, Soh1, or CGI-125, is a 131 amino acid protein that plays a crucial role in the regulation of gene expression. Med31 (3-9D) monoclonal antibody is a key component of the Mediator complex, which serves as a bridge between transcriptional activators and the basal transcription machinery, facilitating the assembly of a functional preinitiation complex with RNA polymerase II and general transcription factors. The importance of Med31 lies in its evolutionary conservation and essential function in coordinating cellular processes by regulating the expression of large sets of genes. Notably, Med31 is required for normal levels of gene conversion during meiosis, highlighting its significance in reproductive biology and genetic diversity. Using anti-Med31 antibody (3-9D) in research can provide valuable insights into the mechanisms of transcription regulation and the broader implications for cellular function and development.

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Med31 Antibody (3-9D) References:

1. The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator.  |  Linder, T. and Gustafsson, CM. 2004. J Biol Chem. 279: 49455-9. PMID: 15356001
2. A high resolution protein interaction map of the yeast Mediator complex.  |  Guglielmi, B., et al. 2004. Nucleic Acids Res. 32: 5379-91. PMID: 15477388
3. Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.  |  van de Peppel, J., et al. 2005. Mol Cell. 19: 511-22. PMID: 16109375
4. TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo.  |  Guglielmi, B., et al. 2007. Proc Natl Acad Sci U S A. 104: 16062-7. PMID: 17901206
5. Genomic expression patterns in cell separation mutants of Schizosaccharomyces pombe defective in the genes sep10 (+) and sep15 (+) coding for the Mediator subunits Med31 and Med8.  |  Miklos, I., et al. 2008. Mol Genet Genomics. 279: 225-38. PMID: 17922236
6. Novel roles for selected genes in meiotic DNA processing.  |  Jordan, PW., et al. 2007. PLoS Genet. 3: e222. PMID: 18069899
7. Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dMED31.  |  Bosveld, F., et al. 2008. Dev Biol. 313: 802-13. PMID: 18083158

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Med31 Antibody (3-9D) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Med31 Antibody (3-9D) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Med31 Antibody (3-9D) Specifications

Alternate Product Name: Med31

Product Clone Name: 3-9D

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-132

Epitope Target: Med31

Epitope Species: human

Product Reactivity/Detection: Med31

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG_2b kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Med31 Antibody (3-9D): N/A