MCR Antibody (4i342): sc-71554
- MCR Antibody (4i342) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against aldosterone 3 coupled to bovine serum albumin
- recommended for detection of MCR of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See MCR (H10E4C9F): sc-53000 for MCR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MCR Antibody (4i342) for WB and IHC(P) applications. These reagents are now offered in bundles with MCR Antibody (4i342) (see ordering information below).
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MCR Antibody (4i342) is a mouse monoclonal IgG1 antibody that detects mineralocorticoid receptor (MCR) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). MCR plays a crucial role in the regulation of electrolyte balance and blood pressure by mediating the effects of mineralocorticoid hormones like aldosterone. Anti-MCR antibody (4i342) recognizes MCR primarily in epithelial tissues, where MCR facilitates the transport of sodium, potassium, and hydrogen ions, thereby influencing fluid balance and vascular health. MCR′s presence in the kidney, colon, and heart underscores MCR′s vital role in maintaining homeostasis and responding to physiological stressors. Upon aldosterone binding, MCR undergoes a conformational change that allows MCR to activate gene transcription, leading to the expression of proteins involved in ion transport. Additionally, MCR interaction with heat shock protein 90 (HSP90) is essential for proper functioning, as this association is necessary for hormone binding and subsequent receptor activation. Anti-MCR antibody (4i342) serves as an invaluable tool for researchers studying the mechanisms of blood pressure regulation and electrolyte homeostasis, providing insights into the pathophysiology of conditions such as hypertension and heart failure.
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MCR Antibody (4i342) References:
- The Promiscuous Mineralocorticoid Receptor. | Funder, JW. 2016. Hypertension. 67: 839-40. PMID: 27045025
- Mineralocorticoid Receptor Antagonists in Primary Aldosteronism. | Stavropoulos, K., et al. 2018. Curr Pharm Des. 24: 5508-5516. PMID: 30854950
- Mineralocorticoid Receptor and Endothelial Dysfunction in Hypertension. | Faulkner, JL. and Belin de Chantemèle, EJ. 2019. Curr Hypertens Rep. 21: 78. PMID: 31485760
- Mineralocorticoid Receptor Antagonists and Cardiovascular Health with Kidney Failure. | Soomro, QH. and Charytan, DM. 2021. Clin J Am Soc Nephrol. 16: 843-845. PMID: 34117077
- Mineralocorticoid receptor antagonists, heart failure and predictive biomarkers. | Karthigan, N., et al. 2022. J Endocrinol. 253: R65-R76. PMID: 35266453
- Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage. | Fels, B., et al. 2022. Pflugers Arch. 474: 1069-1076. PMID: 35867189
- Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia. | Biwer, LA., et al. 2023. Circ Res. 132: 674-689. PMID: 36815487
- Mineralocorticoid receptor antagonists in cardiovascular translational biology. | Chilton, RJ. and Silva-Cardoso, J. 2023. Cardiovasc Endocrinol Metab. 12: e0289. PMID: 37614245
- Mineralocorticoid receptor promotes cardiac macrophage inflammaging. | Fraccarollo, D., et al. 2024. Basic Res Cardiol. 119: 243-260. PMID: 38329499
- Mineralocorticoid receptor antagonists in kidney transplantation. | Kanbay, M., et al. 2024. Eur J Clin Invest. 54: e14206. PMID: 38578116
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCR Antibody (4i342) | sc-71554 | 200 µg/ml | $316.00 | |||
MCR Antibody (4i342): m-IgG Fc BP-HRP Bundle | sc-539374 | 200 µg Ab; 10 µg BP | $354.00 | |||
MCR Antibody (4i342): m-IgG1 BP-HRP Bundle | sc-541443 | 200 µg Ab; 20 µg BP | $354.00 |