MCPIP Antibody (H-6): sc-515275

MCPIP Antibody (H-6) is a mouse monoclonal IgM antibody that detects MCPIP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MCPIP antibody (H-6) is available as a non-conjugated format. MCPIP protein, also known as ZC3H12A, is a 599 amino acid protein that plays a crucial role in regulating gene expression and cellular responses to stress. MCPIP protein is primarily located in the nucleus, where MCPIP functions as a transcriptional activator, influencing various cellular processes such as apoptosis and angiogenesis. Nuclear localization of MCPIP enables direct interaction with DNA and other nuclear proteins, thereby modulating expression of genes involved in inflammatory responses and cell survival. MCPIP protein is implicated in development of acute monocytic leukemia and is associated with ischemic heart disease, conditions that highlight MCPIP′s significance in both cancer biology and cardiovascular health. MCPIP gene is located on human chromosome 1, which is a large chromosome containing over 3,000 genes and playing a vital role in human genetics.

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MCPIP Antibody (H-6) References:

1. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction.  |  Zhou, L., et al. 2006. Circ Res. 98: 1177-85. PMID: 16574901
2. MCP-1 induces a novel transcription factor with proapoptotic activity.  |  Bidzhekov, K., et al. 2006. Circ Res. 98: 1107-9. PMID: 16690887
3. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.  |  Liang, J., et al. 2008. J Biol Chem. 283: 6337-46. PMID: 18178554
4. Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP).  |  Niu, J., et al. 2008. J Biol Chem. 283: 14542-51. PMID: 18364357
5. Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation.  |  Liang, J., et al. 2008. PLoS One. 3: e2880. PMID: 18682727
6. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.  |  Matsushita, K., et al. 2009. Nature. 458: 1185-90. PMID: 19322177
7. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA.  |  Mizgalska, D., et al. 2009. FEBS J. 276: 7386-99. PMID: 19909337
8. Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy.  |  Wang, K., et al. 2011. J Mol Cell Biol. 3: 360-8. PMID: 21990425
9. Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy.  |  Roy, A. and Kolattukudy, PE. 2012. Cell Signal. 24: 2123-31. PMID: 22820500
10. Transcription factors STAT6 and KLF4 implement macrophage polarization via the dual catalytic powers of MCPIP.  |  Kapoor, N., et al. 2015. J Immunol. 194: 6011-23. PMID: 25934862
11. MCPIP: a key player in macrophage polarization.  |  Kolattukudy, P. 2015. Oncotarget. 6: 28531-2. PMID: 26387135
12. Essential Role of Endothelial MCPIP in Vascular Integrity and Post-Ischemic Remodeling.  |  Jin, Z., et al. 2019. Int J Mol Sci. 20: PMID: 30621250

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MCPIP Antibody (H-6) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-MCPIP Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MCPIP Antibody (H-6) Specifications

Alternate Product Name: Regnase 1

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 508-523

Epitope Target: MCPIP

Epitope Species: human

Product Reactivity/Detection: MCPIP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for MCPIP Antibody (H-6): P: Blocking Peptide