MCP-1 Antibody (S8): sc-52877
- MCP-1 Antibody (S8) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant full length MCP-1 of human origin
- recommended for detection of MCP-1 of human origin by WB, IP and ELISA; non cross-reactive with human IL-8 and other human cytokines tested (IL-1fl, serum amyloid A and EGF)
- See MCP-1-4/eotaxin (B-2): sc-377082 for MCP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MCP-1 Antibody (S8). This work is in progress.
MCP-1 Antibody (S8) is a mouse monoclonal IgG1 antibody that detects MCP-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). MCP-1, also known as CCL2, plays a crucial role in the immune response by mediating the recruitment of monocytes to sites of inflammation, which is vital for effective immune surveillance and tissue repair. This chemokine is primarily produced by activated T lymphocytes and various other cell types in response to pro-inflammatory cytokines like interleukin-1, tumor necrosis factor-alpha, and interferon-gamma. The ability of MCP-1 to attract monocytes is essential for initiating and sustaining inflammatory responses, particularly during infections and tissue injury. Notably, MCP-1 interacts with two distinct receptors, CCR2 and CCR4, which are involved in different signaling pathways that regulate immune cell migration and activation. The presence of MCP-1 is often elevated in various pathological conditions, including chronic inflammatory diseases and cancer, making MCP-1 a significant biomarker for disease progression and a potential therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MCP-1 Antibody (S8) References:
- MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission. | Modi, WS., et al. 2003. AIDS. 17: 2357-65. PMID: 14571188
- MCP-1 production in temporomandibular joint inflammation. | Ogura, N., et al. 2010. J Dent Res. 89: 1117-22. PMID: 20647497
- MCP-1 contributes to arteriovenous fistula failure. | Juncos, JP., et al. 2011. J Am Soc Nephrol. 22: 43-8. PMID: 21115617
- MCP-1 stimulates spinal microglia via PI3K/Akt pathway in bone cancer pain. | Jin, D., et al. 2015. Brain Res. 1599: 158-67. PMID: 25555372
- MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis. | Galán, A., et al. 2018. PLoS One. 13: e0190474. PMID: 29304171
- MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis. | Dutta, P., et al. 2018. Breast Cancer Res Treat. 170: 477-486. PMID: 29594759
- Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain. | Zhang, K., et al. 2018. J Neuroinflammation. 15: 197. PMID: 29976212
- Association of MCP-1 promoter polymorphism with susceptibility to nasopharyngeal carcinoma. | Niu, Y., et al. 2019. J Cell Biochem. 120: 6661-6670. PMID: 30368911
- NFAT5 promotes arteriogenesis via MCP-1-dependent monocyte recruitment. | Lin, XC., et al. 2020. J Cell Mol Med. 24: 2052-2063. PMID: 31883300
- The CCR2/MCP-1 Chemokine Pathway and Lung Adenocarcinoma. | Mittal, P., et al. 2020. Cancers (Basel). 12: PMID: 33322474
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCP-1 Antibody (S8) | sc-52877 | 100 µg/ml | $322.00 |