MCM7 Antibody (DCS-141): sc-65469

MCM7 Antibody (DCS-141) is a mouse monoclonal IgG1 kappa light chain antibody that detects MCM7 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MCM7 (DCS-141) antibody is available in a non-conjugated form, allowing for versatile experimental use. The mini-chromosome maintenance (MCM) family, which includes MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7, plays a crucial role in regulating DNA replication, ensuring that DNA is replicated only once per cell cycle. MCM7 is essential for the formation of the MCM2-7 complex, which acts as a helicase during DNA replication, unwinding the double-stranded DNA to allow for the synthesis of new strands. This helicase activity is vital for maintaining genomic stability and preventing replication errors, which can lead to mutations and cancer. The expression of MCM proteins, including MCM7, is tightly regulated throughout the cell cycle, peaking during the transition from the G1 to S phase, and is influenced by E2F transcription factors and various protein kinases. Understanding MCM7 function and regulation is important for elucidating DNA replication mechanisms and potential implications in cancer biology, making anti-MCM7 antibody (DCS-141) a valuable tool for researchers studying cell cycle dynamics and genomic integrity.

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MCM7 Antibody (DCS-141) References:

1. Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathological analysis.  |  Li, SS., et al. 2005. Histopathology. 46: 307-13. PMID: 15720416
2. MCM7 amplification and overexpression are associated with prostate cancer progression.  |  Ren, B., et al. 2006. Oncogene. 25: 1090-8. PMID: 16247466
3. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis.  |  Honeycutt, KA., et al. 2006. Oncogene. 25: 4027-32. PMID: 16518415
4. Oncogenic activity of MCM7 transforming cluster.  |  Luo, JH. 2011. World J Clin Oncol. 2: 120-4. PMID: 21603321
5. Phosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation.  |  Wei, Q., et al. 2013. J Biol Chem. 288: 19715-25. PMID: 23720738
6. MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function.  |  Kang, W., et al. 2014. Oncol Rep. 31: 2071-8. PMID: 24647462
7. MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway.  |  Qiu, YT., et al. 2017. Oncol Rep. 37: 3590-3596. PMID: 28498460
8. Computational Screening of Natural Compounds for Identification of Potential Anti-Cancer Agents Targeting MCM7 Protein.  |  Alshahrani, MY., et al. 2021. Molecules. 26: PMID: 34641424
9. RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells.  |  Sun, Q., et al. 2024. Life Sci. 353: 122912. PMID: 39004272
10. SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM.  |  Duan, H., et al. 2024. Sci China Life Sci.. PMID: 39455502

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MCM7 Antibody (DCS-141) has 21 citations in a variety of scientific publications.

Primary antibodies like Anti-MCM7 Antibody (DCS-141) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MCM7 Antibody (DCS-141) Specifications

Alternate Product Name: MCM7

Product Clone Name: DCS-141

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: MCM7

Epitope Species: human

Product Reactivity/Detection: MCM7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 21 citations in various scientific publications

Available Conjugates/Forms for MCM7 Antibody (DCS-141): N/A

The preferred MCM7 antibody is MCM7 Antibody (141.2): sc-9966.