MCM7 Antibody (47DC141): sc-56324

MCM7 Antibody (47DC141) is a mouse monoclonal IgG1 antibody that detects MCM7 in mouse, rat, human, Xenopus, and canine samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MCM7, a member of the mini-chromosome maintenance (MCM) protein family, plays a crucial role in the regulation of DNA replication, ensuring that DNA is replicated only once per cell cycle. MCM7 is vital for maintaining genomic stability and preventing over-replication, which can lead to genomic instability and cancer. MCM7, along with other MCM proteins, is essential for the formation of the MCM2-7 complex, which acts as a helicase during DNA replication, unwinding the double-stranded DNA to allow for the synthesis of new strands. MCM7 expression is tightly regulated, peaking during the transition from the G1 to S phase of the cell cycle, and is influenced by various factors, including E2F transcription factors and protein kinases. MCM7′s ability to interact with other proteins in the MCM complex underscores its importance in the orchestration of DNA replication and cell cycle progression, making MCM7 a significant target for research in cancer biology and cell cycle regulation.

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MCM7 Antibody (47DC141) References:

1. MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma.  |  Zhou, YM., et al. 2012. Liver Int. 32: 1505-9. PMID: 22784096
2. Interaction of MCM7 and RACK1 for activation of MCM7 and cell growth.  |  Zhang, XY., et al. 2013. Am J Pathol. 182: 796-805. PMID: 23313748
3. MCM7 expression is altered in rat after spinal cord injury.  |  Chen, J., et al. 2013. J Mol Neurosci. 51: 82-91. PMID: 23526403
4. Overexpression of G9a and MCM7 in oesophageal squamous cell carcinoma is associated with poor prognosis.  |  Zhong, X., et al. 2015. Histopathology. 66: 192-200. PMID: 24805087
5. MCM7 expression is a promising predictor of recurrence in patients surgically resected for meningiomas.  |  Winther, TL. and Torp, SH. 2017. J Neurooncol. 131: 575-583. PMID: 27868157
6. RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.  |  Fei, L., et al. 2017. Oncotarget. 8: 40501-40513. PMID: 28465488
7. MCM7 expression is correlated with histological subtypes of lung adenocarcinoma and predictive of poor prognosis.  |  Wang, H., et al. 2017. Int J Clin Exp Pathol. 10: 11747-11753. PMID: 31966536
8. CDC45 modulates MCM7 expression and inhibits cell proliferation by suppressing the PI3K/AKT pathway in acute myeloid leukemia.  |  Zhang, R., et al. 2021. Am J Transl Res. 13: 10218-10232. PMID: 34650692
9. In silico investigation of the role of vitamins in cancer therapy through inhibition of MCM7 oncoprotein.  |  Mukherjee, S., et al. 2022. RSC Adv. 12: 31004-31015. PMID: 36349041
10. Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer.  |  Lashen, AG., et al. 2024. Pathobiology. 1-10. PMID: 39191229

The preferred MCM7 antibody is MCM7 Antibody (141.2): sc-9966.