Mcm4 Antibody (D-7): sc-166037
- Mcm4 Antibody (D-7) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Mcm4 of Saccharomyces cerevisiae origin
- recommended for detection of Mcm4 of y origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Mcm4 Antibody (D-7) for WB applications. These reagents are now offered in bundles with Mcm4 Antibody (D-7) (see ordering information below).
Mcm4 Antibody (D-7) is a mouse monoclonal IgG2a antibody that detects Mcm4 in various species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mcm4 is a crucial member of the mini-chromosome maintenance (MCM) protein family, which plays a vital role in DNA replication regulation, ensuring DNA replicates once during each cell cycle. Mcm4, along with Mcm2, Mcm3, Mcm5, Mcm6, and Mcm7, forms a complex exhibiting DNA helicase activity, essential for unwinding double-stranded DNA during replication. This helicase activity drives cell cycle progression, particularly during G1 to S phase transition where DNA synthesis occurs. E2F transcription factors and various protein kinases tightly control Mcm4 regulation, helping maintain cellular postreplicative state. Mcm4 interacts with other MCM proteins to form a functional complex essential for DNA replication initiation, making anti-Mcm4 antibody (D-7) an invaluable tool for studying cell proliferation and cancer research.
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Mcm4 Antibody (D-7) References:
- Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication. | Kudoh, A., et al. 2006. J Virol. 80: 10064-72. PMID: 17005684
- Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells. | Yun, HJ., et al. 2012. Mol Cell Biochem. 363: 281-9. PMID: 22160829
- Prognostic significance of minichromosome maintenance proteins in breast cancer. | Kwok, HF., et al. 2015. Am J Cancer Res. 5: 52-71. PMID: 25628920
- MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions. | Choy, B., et al. 2016. Hum Pathol. 57: 126-135. PMID: 27476776
- Role of Amygdalin in Blocking DNA Replication in Breast Cancer In Vitro. | Albogami, S. and Alnefaie, A. 2021. Curr Pharm Biotechnol. 22: 1612-1627. PMID: 33535947
- Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target. | Misono, S., et al. 2021. Cancers (Basel). 13: PMID: 33801812
- Potential Prospective Biomarkers for Non-small Cell Lung Cancer: Mini-Chromosome Maintenance Proteins. | Huang, C., et al. 2021. Front Genet. 12: 587017. PMID: 33936158
- MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer. | Hsu, EC., et al. 2021. Sci Rep. 11: 13305. PMID: 34172788
- The Alterations and Potential Roles of MCMs in Breast Cancer. | Liu, X., et al. 2021. J Oncol. 2021: 7928937. PMID: 34475953
- Identification of novel biomarkers in breast cancer via integrated bioinformatics analysis and experimental validation. | Wang, N., et al. 2021. Bioengineered. 12: 12431-12446. PMID: 34895070
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mcm4 Antibody (D-7) | sc-166037 | 200 µg/ml | $322.00 | |||
Mcm4 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-537431 | 200 µg Ab; 10 µg BP | $361.00 | |||
Mcm4 Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-534695 | 200 µg Ab; 40 µg BP | $361.00 | |||
Mcm4 Antibody (D-7): m-IgG2a BP-HRP Bundle | sc-548014 | 200 µg Ab; 10 µg BP | $361.00 |