Mcl-1 Antibody (C-2): sc-377487
- Mcl-1 Antibody (C-2) is a mouse monoclonal IgM κ, cited in 8 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 111-149 within an internal region of Mcl-1 of human origin
- recommended for detection of Mcl-1 long and short forms of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine and canine
- See Mcl-1 (22): sc-12756 for Mcl-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Mcl-1 Antibody (C-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with Mcl-1 Antibody (C-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
Mcl-1 Antibody (C-2) is a mouse monoclonal IgM kappa light chain antibody specific for an epitope mapping between amino acids 111-149 within an internal region of human Mcl-1, designed to detect both long and short forms of Mcl-1 from mouse, rat, and human origins via western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. Mcl-1, also called Myeloid cell leukemia-1, Mcl1, and Gm52627, is a critical anti-apoptotic protein within the B-cell lymphoma 2 (Bcl-2) family that plays a vital role in regulating cell survival by inhibiting apoptosis through interactions with pro-apoptotic proteins like Bak and Bax, thereby preventing mitochondrial outer membrane permeabilization and cytochrome c release, essential steps in the intrinsic apoptotic pathway. Mcl-1 functions to ensure normal development, tissue homeostasis, and immune system function, particularly in the maintenance of B and T lymphocyte populations. Dysregulation or overexpression of Mcl-1 can lead to the survival of abnormal cells and has been implicated in the development of various cancers, including leukemia, lymphoma, and solid tumors, making Mcl-1 an important target for cancer research and therapeutic intervention. Understanding Mcl-1′s function and interactions is therefore essential for elucidating the mechanisms of cell death and survival, and anti-Mcl-1 antibody (C-2) serves as a valuable tool for researchers studying these processes in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mcl-1 Antibody (C-2) | sc-377487 | 200 µg/ml | $322.00 | |||
Mcl-1 Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-552486 | 200 µg Ab; 40 µg BP | $361.00 | |||
Mcl-1 (C-2) Neutralizing Peptide | sc-377487 P | 100 µg/0.5 ml | $69.00 |