MCCA Antibody (A-4): sc-271427

MCCA Antibody (A-4) is a mouse monoclonal IgG2a antibody that detects methylcrotonoyl-CoA carboxylase α chain (MCCA) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MCCA antibody (A-4) plays a vital role in studying the function of MCCA, which is essential for the catabolism of the branched-chain amino acid leucine. MCCA (A-4) antibody targets an enzyme located in the mitochondrial matrix, where MCCA operates as a heterodimer to catalyze the carboxylation of 3-methylcrotonyl-CoA into 3-methylglutaconyl-CoA, a critical step in the metabolic pathway. The importance of MCCA′s function is underscored by its involvement in metabolic disorders; defects in the gene encoding MCCA can lead to 3-methylcrotonylglycinuria, an autosomal recessive condition that manifests with symptoms ranging from muscular hypotonia to severe metabolic crises. MCCA consists of 725 amino acids and is encoded by a gene located on chromosome 3q26-q28, which includes 19 exons. Understanding the role of MCCA and its associated pathways is crucial for developing therapeutic strategies for related metabolic disorders, making MCCA monoclonal antibody (A-4) an invaluable tool for researchers in the field.

The preferred MCCA antibody is MCCA Antibody (B-7): sc-365754.