MBNL3 Antibody (5A11): sc-136168

MBNL3 Antibody (5A11) is a mouse monoclonal IgG1 antibody that detects MBNL3 in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. MBNL3, a 354 amino acid protein, plays a crucial role in the regulation of muscle differentiation, acting as an inhibitor of this process, which contrasts with MBNL1 and MBNL2 that promote muscle differentiation. MBNL3′s inhibitory role is particularly significant in myotonic dystrophies, where protein balance can significantly influence muscle pathology. MBNL3 is predominantly expressed in the placenta, indicating potential involvement in developmental processes and tissue-specific functions. MBNL3′s ability to interact with expanded CUG repeats in vitro suggests a role in myotonic dystrophy pathogenesis by modulating pre-mRNA splicing associated with muscle function. Anti-MBNL3 antibody (5A11) serves as an essential tool for researchers investigating molecular mechanisms underlying muscle differentiation and related disorders.