MAZ Antibody (133.7): sc-130915
- MAZ Antibody (133.7) is a mouse monoclonal IgG2a κ MAZ antibody, cited in 7 publications, provided at 200 µg/ml
- raised against a heparin-agarose purified MAZ-maltose binding fusion protein of human origin
- MAZ Antibody (133.7) is recommended for detection of MAZ of mouse, rat and human origin by WB, IP and IF
- Anti-MAZ Antibody (133.7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MAZ Antibody (133.7) for WB applications. These reagents are now offered in bundles with MAZ Antibody (133.7) (see ordering information below).
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MAZ Antibody (133.7) is a mouse monoclonal IgG2a kappa light chain antibody that detects MAZ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-MAZ antibody (133.7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Myc-associated zinc finger protein MAZ, also known as ZF87 or Pur-1 in mouse, is a crucial transcription factor that plays a significant role in regulating gene expression by participating in both initiation and termination of transcription. MAZ functions as a transcriptional repressor, exerting effects independently of the c-Myc promoter, which is essential for maintaining proper cellular function and preventing aberrant gene expression. MAZ protein is primarily located in the nucleus, where MAZ interacts with various transcription factors, including SP1, to modulate the expression of genes such as the parathyroid hormone receptor and serotonin 1A receptor. This interaction is vital for tissue-specific gene expression, as competition between MAZ and SP1 can influence the regulation of the PNMT gene, highlighting MAZ′s importance in cellular differentiation and development. MAZ′s role as a growth suppressor protein is underscored by MAZ′s ability to impact the levels of key cell cycle regulatory proteins, such as cyclin A and E, thereby contributing to the control of cell proliferation and prevention of tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAZ Antibody (133.7) References:
- Phenylethanolamine N-methyltransferase gene expression. Sp1 and MAZ potential for tissue-specific expression. | Her, S., et al. 1999. J Biol Chem. 274: 8698-707. PMID: 10085109
- Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene. | Song, J., et al. 1999. Eur J Biochem. 259: 676-83. PMID: 10092852
- Transcriptional repression from the c-myc P2 promoter by the zinc finger protein ZF87/MAZ. | Izzo, MW., et al. 1999. J Biol Chem. 274: 19498-506. PMID: 10383467
- Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. | Jordan-Sciutto, KL., et al. 2000. Biochemistry. 39: 3206-15. PMID: 10727212
- The ZF87/MAZ transcription factor functions as a growth suppressor in fibroblasts. | Stubbs, MC., et al. 2000. Biochem Cell Biol. 78: 477-85. PMID: 11012087
- The transcription factors SP1 and MAZ regulate expression of the parathyroid hormone/parathyroid hormone-related peptide receptor gene. | Williams, LJ. and Abou-Samra, AB. 2000. J Mol Endocrinol. 25: 309-19. PMID: 11116210
- The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. | Parks, CL. and Shenk, T. 1996. J Biol Chem. 271: 4417-30. PMID: 8626793
- Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ). | Song, J., et al. 1998. J Biol Chem. 273: 20603-14. PMID: 9685418
- Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. | Song, J., et al. 1998. Genomics. 52: 374-7. PMID: 9790757
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAZ Antibody (133.7) | sc-130915 | 200 µg/ml | $322.00 | |||
MAZ Antibody (133.7): m-IgG Fc BP-HRP Bundle | sc-528738 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAZ Antibody (133.7): m-IgGκ BP-HRP Bundle | sc-521219 | 200 µg Ab, 40 µg BP | $361.00 | |||
MAZ Antibody (133.7): m-IgG2a BP-HRP Bundle | sc-547155 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAZ Antibody (133.7) AC | sc-130915 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MAZ Antibody (133.7) HRP | sc-130915 HRP | 200 µg/ml | $322.00 | |||
MAZ Antibody (133.7) FITC | sc-130915 FITC | 200 µg/ml | $336.00 | |||
MAZ Antibody (133.7) PE | sc-130915 PE | 200 µg/ml | $349.00 | |||
MAZ Antibody (133.7) Alexa Fluor® 488 | sc-130915 AF488 | 200 µg/ml | $364.00 | |||
MAZ Antibody (133.7) Alexa Fluor® 546 | sc-130915 AF546 | 200 µg/ml | $364.00 | |||
MAZ Antibody (133.7) Alexa Fluor® 594 | sc-130915 AF594 | 200 µg/ml | $364.00 | |||
MAZ Antibody (133.7) Alexa Fluor® 647 | sc-130915 AF647 | 200 µg/ml | $364.00 | |||
MAZ Antibody (133.7) Alexa Fluor® 680 | sc-130915 AF680 | 200 µg/ml | $364.00 | |||
MAZ Antibody (133.7) Alexa Fluor® 790 | sc-130915 AF790 | 200 µg/ml | $364.00 |