MATH-3 Antibody (D-10): sc-393724
- MATH-3 Antibody (D-10) is a mouse monoclonal IgG1 κ MATH-3 antibody provided at 200 µg/ml
- raised against amino acids 75-286 mapping within an internal region of MATH-3 of human origin
- MATH-3 Antibody (D-10) is recommended for detection of MATH-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MATH-3 Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MATH-3 Antibody (D-10) for WB applications. These reagents are now offered in bundles with MATH-3 Antibody (D-10) (see ordering information below).
QUICK LINKS
MATH-3 Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects MATH-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MATH-3 (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MATH-3 protein, a member of the Neurogenin family, plays a crucial role in the development of the nervous system by acting as a transcriptional regulator that influences cell fate decisions during neurogenesis. Specifically, MATH-3 is involved in the differentiation of neuronal precursors, particularly in the dorsal regions of the hindbrain and spinal cord, where MATH-3 contributes to the formation of sensory neurons. Understanding MATH-3 function is vital, as MATH-3 helps elucidate the mechanisms underlying neuronal development and the potential implications in neurodevelopmental disorders. MATH-3 gene is located on mouse chromosome 10, and MATH-3 human homolog, HATH-1, shares a high degree of sequence identity, mapping to human chromosome 4q22. This conservation across species highlights MATH-3 importance in neural development and MATH-3 potential as a target for research into neurogenesis and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MATH-3 Antibody (D-10) References:
- neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. | Gradwohl, G., et al. 2000. Proc Natl Acad Sci U S A. 97: 1607-11. PMID: 10677506
- Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. | Huang, HP., et al. 2000. Mol Cell Biol. 20: 3292-307. PMID: 10757813
- Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. | Jacquemin, P., et al. 2000. Mol Cell Biol. 20: 4445-54. PMID: 10825208
- Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. | Jensen, J., et al. 2000. Diabetes. 49: 163-76. PMID: 10868931
- Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. | Schwitzgebel, VM., et al. 2000. Development. 127: 3533-42. PMID: 10903178
- Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. | Ben-Arie, N., et al. 1996. Hum Mol Genet. 5: 1207-16. PMID: 8872459
- NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. | Tamimi, RM., et al. 1997. Genomics. 40: 355-7. PMID: 9119405
- neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. | Ma, Q., et al. 1998. Neuron. 20: 469-82. PMID: 9539122
- The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. | Fode, C., et al. 1998. Neuron. 20: 483-94. PMID: 9539123
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MATH-3 Antibody (D-10) | sc-393724 | 200 µg/ml | $322.00 | |||
MATH-3 Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-530559 | 200 µg Ab; 10 µg BP | $361.00 | |||
MATH-3 Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-524065 | 200 µg Ab, 40 µg BP | $361.00 | |||
MATH-3 Antibody (D-10): m-IgG1 BP-HRP Bundle | sc-544130 | 200 µg Ab; 20 µg BP | $361.00 | |||
MATH-3 Antibody (D-10) AC | sc-393724 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MATH-3 Antibody (D-10) HRP | sc-393724 HRP | 200 µg/ml | $322.00 | |||
MATH-3 Antibody (D-10) FITC | sc-393724 FITC | 200 µg/ml | $336.00 | |||
MATH-3 Antibody (D-10) PE | sc-393724 PE | 200 µg/ml | $349.00 | |||
MATH-3 Antibody (D-10) Alexa Fluor® 488 | sc-393724 AF488 | 200 µg/ml | $364.00 | |||
MATH-3 Antibody (D-10) Alexa Fluor® 546 | sc-393724 AF546 | 200 µg/ml | $364.00 | |||
MATH-3 Antibody (D-10) Alexa Fluor® 594 | sc-393724 AF594 | 200 µg/ml | $364.00 | |||
MATH-3 Antibody (D-10) Alexa Fluor® 647 | sc-393724 AF647 | 200 µg/ml | $364.00 | |||
MATH-3 Antibody (D-10) Alexa Fluor® 680 | sc-393724 AF680 | 200 µg/ml | $364.00 | |||
MATH-3 Antibody (D-10) Alexa Fluor® 790 | sc-393724 AF790 | 200 µg/ml | $364.00 |