Mast Cell Tryptase Antibody (AA1): sc-59587

Mast Cell Tryptase Antibody (AA1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mast Cell Tryptase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Mast Cell Tryptase antibody (AA1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mast cells, which are derived from blood-forming tissues, play a crucial role in mediating inflammatory and immune responses by secreting various substances. Mast Cell Tryptase is a member of the tryptase family, which consists of serine proteases that are enzymatically active as heparin-stabilized tetramers. These enzymes are primarily expressed in mast cells and are involved in several physiological processes, including the generation of vasoactive peptides and the degradation of the extracellular matrix. The human tryptase genes, located on chromosome 16p13.3, include four functional genes: α I, β I, β II, and γ I, with β tryptases being the predominant isoenzymes in mast cells. Understanding the structure and function of Mast Cell Tryptase is essential, as this protein not only contributes to the regulation of immune responses but also plays a significant role in various pathological conditions, including allergies and asthma. Using Mast Cell Tryptase (AA1) monoclonal antibody, researchers can gain valuable insights into mast cell biology and the underlying mechanisms of related diseases.

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Mast Cell Tryptase Antibody (AA1) References:

1. Mast cell tryptase and its role in tissue remodelling.  |  Cairns, JA. 1998. Clin Exp Allergy. 28: 1460-3. PMID: 10024215
2. Mast cell tryptase, a still enigmatic enzyme.  |  Fiorucci, L. and Ascoli, F. 2004. Cell Mol Life Sci. 61: 1278-95. PMID: 15170507
3. Biology of mast cell tryptase. An inflammatory mediator.  |  Hallgren, J. and Pejler, G. 2006. FEBS J. 273: 1871-95. PMID: 16640553
4. Mast cell tryptase beta as a target in allergic inflammation: an evolving story.  |  Sommerhoff, CP. and Schaschke, N. 2007. Curr Pharm Des. 13: 313-32. PMID: 17313363
5. Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease.  |  Melo, FR., et al. 2014. J Biol Chem. 289: 7682-90. PMID: 24478313
6. Serum concentrations of mast cell tryptase are reduced in heavy drinkers.  |  Beceiro, C., et al. 2015. Alcohol Clin Exp Res. 39: 672-8. PMID: 25833028
7. Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2.  |  Bagher, M., et al. 2018. Cell Commun Signal. 16: 59. PMID: 30219079
8. Protective role of mouse mast cell tryptase Mcpt6 in melanoma.  |  Grujic, M., et al. 2020. Pigment Cell Melanoma Res. 33: 579-590. PMID: 31894627
9. Mast Cell Tryptase and Carboxypeptidase A3 in the Formation of Ovarian Endometrioid Cysts.  |  Atiakshin, D., et al. 2023. Int J Mol Sci. 24: PMID: 37047472
10. Expression of mast cell tryptase and immunoglobulin E is increased in cutaneous photodamage: implications for carcinogenesis.  |  Korhonen, J., et al. 2024. J Dermatolog Treat. 35: 2307488. PMID: 38291602

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mast Cell Tryptase Antibody (AA1) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-Mast Cell Tryptase Antibody (AA1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mast Cell Tryptase Antibody (AA1) Specifications

Alternate Product Name: Tryptase (TPSAB1)

Product Clone Name: AA1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Mast Cell Tryptase

Epitope Species: human

Product Reactivity/Detection: Mast Cell Tryptase distributed in skin, synovium, lung and heart

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: feline and canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for Mast Cell Tryptase Antibody (AA1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Mast Cell Tryptase antibody is Mast Cell Tryptase Antibody (G3): sc-33676.