MAP-6D1 Antibody (F-6): sc-515352
- MAP-6D1 Antibody (F-6) is a mouse monoclonal IgG1 κ MAP-6D1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 58-77 within an internal region of MAP-6D1 of human origin
- MAP-6D1 Antibody (F-6) is recommended for detection of MAP-6D1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MAP-6D1 Antibody (F-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MAP-6D1 Antibody (F-6) for WB applications. These reagents are now offered in bundles with MAP-6D1 Antibody (F-6) (see ordering information below).
MAP-6D1 Antibody (F-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAP-6D1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAP-6D1 (F-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MAP-6D1 protein, also known as MAP6 domain-containing protein 1 or STOP-like protein 21, is a 199 amino acid neuronal protein that plays a crucial role in stabilizing microtubules and is primarily located within the Golgi apparatus membrane. This localization facilitates MAP-6D1 interaction with calmodulin, a calcium-binding messenger protein essential for various cellular processes, including mitosis regulation. MAP-6D1 interaction with calmodulin is enhanced by palmitoylation of cysteine residues near the N-terminus, which increases MAP-6D1 hydrophobicity and promotes association with cellular membranes. This post-translational modification is vital for MAP-6D1 subcellular trafficking, allowing effective modulation of protein-protein interactions and contribution to microtubule stabilization, thereby playing a key role in maintaining cellular structure and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAP-6D1 Antibody (F-6) References:
- Phosphorylation of microtubule-associated protein STOP by calmodulin kinase II. | Baratier, J., et al. 2006. J Biol Chem. 281: 19561-9. PMID: 16651267
- Myelin basic protein functions as a microtubule stabilizing protein in differentiated oligodendrocytes. | Galiano, MR., et al. 2006. J Neurosci Res. 84: 534-41. PMID: 16773649
- STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. | Gory-Fauré, S., et al. 2006. J Biol Chem. 281: 28387-96. PMID: 16837464
- Deletion of the STOP gene, a microtubule stabilizing factor, leads only to discrete cerebral metabolic changes in mice. | Hanaya, R., et al. 2008. J Neurosci Res. 86: 813-20. PMID: 17969102
- Vinflunine, a novel microtubule inhibitor, suppresses calmodulin interaction with the microtubule-associated protein STOP. | Makarov, AA., et al. 2007. Biochemistry. 46: 14899-906. PMID: 18052208
- Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission. | Bouvrais-Veret, C., et al. 2008. J Neurochem. 104: 745-56. PMID: 18199119
- Cloning, expression, and properties of the microtubule-stabilizing protein STOP. | Bosc, C., et al. 1996. Proc Natl Acad Sci U S A. 93: 2125-30. PMID: 8700896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAP-6D1 Antibody (F-6) | sc-515352 | 200 µg/ml | $322.00 | |||
MAP-6D1 Antibody (F-6): m-IgG Fc BP-HRP Bundle | sc-531344 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAP-6D1 Antibody (F-6): m-IgGκ BP-HRP Bundle | sc-525009 | 200 µg Ab, 40 µg BP | $361.00 | |||
MAP-6D1 Antibody (F-6): m-IgG1 BP-HRP Bundle | sc-544496 | 200 µg Ab; 20 µg BP | $361.00 | |||
MAP-6D1 Antibody (F-6) AC | sc-515352 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MAP-6D1 Antibody (F-6) HRP | sc-515352 HRP | 200 µg/ml | $322.00 | |||
MAP-6D1 Antibody (F-6) FITC | sc-515352 FITC | 200 µg/ml | $336.00 | |||
MAP-6D1 Antibody (F-6) PE | sc-515352 PE | 200 µg/ml | $349.00 | |||
MAP-6D1 Antibody (F-6) Alexa Fluor® 488 | sc-515352 AF488 | 200 µg/ml | $364.00 | |||
MAP-6D1 Antibody (F-6) Alexa Fluor® 546 | sc-515352 AF546 | 200 µg/ml | $364.00 | |||
MAP-6D1 Antibody (F-6) Alexa Fluor® 594 | sc-515352 AF594 | 200 µg/ml | $364.00 | |||
MAP-6D1 Antibody (F-6) Alexa Fluor® 647 | sc-515352 AF647 | 200 µg/ml | $364.00 | |||
MAP-6D1 Antibody (F-6) Alexa Fluor® 680 | sc-515352 AF680 | 200 µg/ml | $364.00 | |||
MAP-6D1 Antibody (F-6) Alexa Fluor® 790 | sc-515352 AF790 | 200 µg/ml | $364.00 | |||
MAP-6D1 (F-6) Neutralizing Peptide | sc-515352 P | 100 µg/0.5 ml | $69.00 |