MAP-1B Antibody (H-8): sc-365668
- MAP-1B Antibody (H-8) is a mouse monoclonal IgG2b κ MAP-1B antibody, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 6-31 at the N-terminus of MAP-1B of human origin
- MAP-1B Antibody (H-8) is recommended for detection of MAP-1B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MAP-1B Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MAP-1B Antibody (H-8) for WB applications. These reagents are now offered in bundles with MAP-1B Antibody (H-8) (see ordering information below).
MAP-1B Antibody (H-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects MAP-1B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAP-1B (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MAP-1B protein plays a crucial role in stabilizing and assembling microtubules, which are essential components of the cytoskeleton that provide structural support and shape to cells. Through interactions with tubulin, MAP-1B enhances microtubule stability and influences their spatial organization within cells, which is vital for processes such as intracellular transport, cell division, and maintaining cell morphology. MAP-1B′s regulation of microtubule dynamics is closely linked to phosphorylation status, which can modulate activity and interactions with other proteins. Understanding MAP-1B function is important for elucidating its role in various cellular processes and implications in diseases associated with cytoskeletal dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAP-1B Antibody (H-8) References:
- Towards an understanding of microtubule function and cell organization: an overview. | MacRae, TH. 1992. Biochem Cell Biol. 70: 835-41. PMID: 1297349
- Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease. | Hasegawa, M., et al. 1990. Neuron. 4: 909-18. PMID: 2361014
- Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p. | Chen, YL. and Shen, CK. 2013. J Neurosci. 33: 9013-20. PMID: 23699512
- MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules. | Arasaki, K., et al. 2018. EMBO Rep. 19: PMID: 29925525
- Role of tubulin-associated proteins in microtubule nucleation and elongation. | Murphy, DB., et al. 1977. J Mol Biol. 117: 33-52. PMID: 599568
- Role of microtubule-associated proteins in the control of microtubule assembly. | Maccioni, RB. and Cambiazo, V. 1995. Physiol Rev. 75: 835-64. PMID: 7480164
- Modulation of microtubule dynamic instability in vivo by brain microtubule associated proteins. | Dhamodharan, R. and Wadsworth, P. 1995. J Cell Sci. 108 (Pt 4): 1679-89. PMID: 7615685
- The mitogen-activated protein kinase signal transduction pathway. | Davis, RJ. 1993. J Biol Chem. 268: 14553-6. PMID: 8325833
- MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth. | DiTella, MC., et al. 1996. J Cell Sci. 109 (Pt 2): 467-77. PMID: 8838670
- Differences in the regulation of microtubule dynamics by microtubule-associated proteins MAP1B and MAP2. | Vandecandelaere, A., et al. 1996. Cell Motil Cytoskeleton. 35: 134-46. PMID: 8894283
- Differential regulation of microtubule-associated protein 1B (MAP1B) in rat CNS and PNS during development. | Ma, D., et al. 1997. J Neurosci Res. 49: 319-32. PMID: 9260743
- Microtubule-associated proteins and the stimulation of tubulin assembly in vitro. | Sloboda, RD., et al. 1976. Biochemistry. 15: 4497-505. PMID: 974072
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAP-1B Antibody (H-8) | sc-365668 | 200 µg/ml | $322.00 | |||
MAP-1B Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-529432 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAP-1B Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-522320 | 200 µg Ab, 40 µg BP | $361.00 | |||
MAP-1B Antibody (H-8) AC | sc-365668 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MAP-1B Antibody (H-8) HRP | sc-365668 HRP | 200 µg/ml | $322.00 | |||
MAP-1B Antibody (H-8) FITC | sc-365668 FITC | 200 µg/ml | $336.00 | |||
MAP-1B Antibody (H-8) PE | sc-365668 PE | 200 µg/ml | $349.00 | |||
MAP-1B Antibody (H-8) Alexa Fluor® 488 | sc-365668 AF488 | 200 µg/ml | $364.00 | |||
MAP-1B Antibody (H-8) Alexa Fluor® 546 | sc-365668 AF546 | 200 µg/ml | $364.00 | |||
MAP-1B Antibody (H-8) Alexa Fluor® 594 | sc-365668 AF594 | 200 µg/ml | $364.00 | |||
MAP-1B Antibody (H-8) Alexa Fluor® 647 | sc-365668 AF647 | 200 µg/ml | $364.00 | |||
MAP-1B Antibody (H-8) Alexa Fluor® 680 | sc-365668 AF680 | 200 µg/ml | $364.00 | |||
MAP-1B Antibody (H-8) Alexa Fluor® 790 | sc-365668 AF790 | 200 µg/ml | $364.00 | |||
MAP-1B (H-8) Neutralizing Peptide | sc-365668 P | 100 µg/0.5 ml | $69.00 |