MAP-1B Antibody (AA9): sc-80014

MAP-1B Antibody (AA9) is a mouse monoclonal IgG2a antibody that detects MAP-1B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). MAP-1B is a crucial microtubule-associated protein that plays a significant role in the stabilization and assembly of microtubules, which are essential components of the cytoskeletal network. MAP-1B is primarily located in the cytoplasm, where MAP-1B interacts with tubulin to promote microtubule stability and organization, thereby influencing cellular shape and transport processes. Proper functioning of MAP-1B is vital for maintaining cellular integrity and facilitating intracellular transport, as disruptions in microtubule dynamics can lead to various diseases, including neurodegenerative disorders. Additionally, MAP-1B undergoes post-translational modifications, such as phosphorylation, which can regulate MAP-1B activity and interactions with other proteins, further underscoring MAP-1B importance in cellular processes. Anti-MAP-1B antibody (AA9) is an invaluable tool for researchers studying microtubule dynamics and the role of microtubule-associated proteins in health and disease.

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MAP-1B Antibody (AA9) References:

1. MAP1B expression and microtubule stability in growing and regenerating axons.  |  Gordon-Weeks, PR. and Fischer, I. 2000. Microsc Res Tech. 48: 63-74. PMID: 10649507
2. Phosphorylated MAP-1B isoforms in the developing mouse barrel cortex.  |  Majewska, B. and Skangiel-Kramska, J. 2000. Int J Dev Neurosci. 18: 113-9. PMID: 10708912
3. MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS.  |  Schoenfeld, TA., et al. 1989. J Neurosci. 9: 1712-30. PMID: 2470876
4. Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice.  |  Gödel, M., et al. 2015. PLoS One. 10: e0140116. PMID: 26448484
5. The GSK3-MAP1B pathway controls neurite branching and microtubule dynamics.  |  Barnat, M., et al. 2016. Mol Cell Neurosci. 72: 9-21. PMID: 26773468
6. Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.  |  Bodaleo, FJ., et al. 2016. Sci Rep. 6: 30069. PMID: 27425640
7. A microtubule-associated protein MAP1B binds to and regulates localization of a calcium-binding protein ALG-2.  |  Takahara, T., et al. 2018. Biochem Biophys Res Commun. 497: 492-498. PMID: 29432744
8. Microtubule-associated proteins, MAP 1A and MAP 1B, interact with F-actin in vitro.  |  Fujii, T., et al. 1993. J Biochem. 114: 827-9. PMID: 7908020
9. Microtubule-associated protein 1b (MAP1b) is concentrated in the distal region of growing axons.  |  Black, MM., et al. 1994. J Neurosci. 14: 857-70. PMID: 8301365
10. The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses.  |  Hanley, JG., et al. 1999. Nature. 397: 66-9. PMID: 9892354

The preferred MAP-1B antibody is MAP-1B Antibody (H-8): sc-365668.