MAP-1B Antibody (AA6): sc-58784
- MAP-1B Antibody (AA6) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against brain microtubule associated proteins of rat origin
- recommended for detection of MAP-1B of mouse, rat, human, bovine and feline origin by WB, IF and IHC(P); non cross-reactive with tubulin of other Microtubule associated proteins
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MAP-1B Antibody (AA6) for WB and IHC(P) applications. These reagents are now offered in bundles with MAP-1B Antibody (AA6) (see ordering information below).
MAP-1B Antibody (AA6) is a mouse monoclonal IgG1 antibody that detects MAP-1B in mouse, rat, human, bovine, and feline samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). MAP-1B plays a crucial role in the stabilization and assembly of microtubules, which are essential components of the cytoskeleton that provide structural support and shape to cells. MAP-1B is primarily located in the cytoplasm, where MAP-1B interacts with tubulin to promote microtubule formation and stability, thereby influencing cellular processes such as intracellular transport, cell division, and maintenance of cell shape. Proper functioning of MAP-1B is vital for neuronal development and function, as MAP-1B helps maintain the integrity of neuronal processes and supports synaptic stability. Dysregulation of MAP-1B has been linked to various neurodegenerative diseases, highlighting MAP-1B′s importance in maintaining cellular health and function. Anti-MAP-1B antibody (AA6) is an invaluable tool for researchers studying microtubule dynamics and their implications in cellular processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAP-1B Antibody (AA6) References:
- MAP1B rescues LRRK2 mutant-mediated cytotoxicity. | Chan, SL., et al. 2014. Mol Brain. 7: 29. PMID: 24754922
- Phosphorylation sites of microtubule-associated protein 1B (MAP 1B) are involved in axon growth and regeneration. | Ishikawa, Y., et al. 2019. Mol Brain. 12: 93. PMID: 31711525
- MACF1 promotes osteoblastic cell migration by regulating MAP1B through the GSK3beta/TCF7 pathway. | Su, P., et al. 2022. Bone. 154: 116238. PMID: 34700040
- Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. | Strohm, L., et al. 2022. Life Sci Alliance. 5: PMID: 35777956
- Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway. | Guo, Y., et al. 2023. Nat Commun. 14: 3801. PMID: 37365192
- A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis. | Inoue, H., et al. 2024. J Cell Biol. 223: PMID: 38353696
- Microtubule-binding protein MAP1B regulates interstitial axon branching of cortical neurons via the tubulin tyrosination cycle. | Ziak, J., et al. 2024. EMBO J. 43: 1214-1243. PMID: 38388748
- FMRP regulates postnatal neuronal migration via MAP1B. | Messaoudi, S., et al. 2024. Elife. 12: PMID: 38757694
- Microtubule-associated protein, MAP1B, encodes functionally distinct polypeptides. | Tan, TC., et al. 2024. J Biol Chem. 300: 107792. PMID: 39305956
- Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. | Lucas, FR., et al. 1998. J Cell Sci. 111 (Pt 10): 1351-61. PMID: 9570753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAP-1B Antibody (AA6) | sc-58784 | 200 µg/ml | $322.00 | |||
MAP-1B Antibody (AA6): m-IgG Fc BP-HRP Bundle | sc-539099 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAP-1B Antibody (AA6): m-IgG1 BP-HRP Bundle | sc-541258 | 200 µg Ab; 20 µg BP | $361.00 |