Manic Fringe Antibody (2B11): sc-517162

Manic Fringe Antibody (2B11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Manic Fringe protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Manic Fringe antibody (2B11) is available as a non-conjugated format. Manic Fringe (2B11) antibody recognizes a protein that plays a crucial role in regulating the Notch signaling pathway, which is essential for various developmental processes, including cell differentiation and boundary formation during embryogenesis. Manic Fringe belongs to the mammalian fringe family, which includes Radical and Lunatic Fringe, all evolutionarily related to the Drosophila fringe protein. Unique expression patterns of these fringe proteins in different tissues highlight their specific functions; while Radical Fringe is vital for limb bud development, Lunatic Fringe is necessary for proper somite segmentation and is believed to be influenced by the molecular clock. Manic Fringe has been implicated in tumorigenesis, as studies have shown tumor formation in mouse NIH/3T3 cells when introduced into severe combined immunodeficient mice. These findings underscore Manic Fringe′s importance in normal development and cancer biology, making Manic Fringe (2B11) monoclonal antibody a valuable research tool for studying these critical processes.

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Manic Fringe Antibody (2B11) References:

1. Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.  |  Zhang, S., et al. 2015. Cancer Res. 75: 1936-43. PMID: 25808869
2. Nuclear and stromal expression of Manic fringe in renal cell carcinoma.  |  Cheng, WK., et al. 2021. Exp Mol Pathol. 122: 104667. PMID: 34371013
3. Downregulation of Manic fringe impedes angiogenesis and cell migration of renal carcinoma.  |  Cheng, WK., et al. 2022. Microvasc Res. 142: 104341. PMID: 35157839
4. Fringe family genes and their modulation of Notch signaling in cancer.  |  Mugisha, S., et al. 2022. Biochim Biophys Acta Rev Cancer. 1877: 188746. PMID: 35660646
5. A pan-cancer analysis revealing the role of LFNG, MFNG and RFNG in tumor prognosis and microenvironment.  |  Gong, X., et al. 2023. BMC Cancer. 23: 1065. PMID: 37932706
6. Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.  |  Laufer, E., et al. 1997. Nature. 386: 366-73. PMID: 9121552
7. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.  |  Johnston, SH., et al. 1997. Development. 124: 2245-54. PMID: 9187150
8. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.  |  Cohen, B., et al. 1997. Nat Genet. 16: 283-8. PMID: 9207795
9. EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic.  |  May, WA., et al. 1997. Nat Genet. 17: 495-7. PMID: 9398859
10. lunatic fringe is an essential mediator of somite segmentation and patterning.  |  Evrard, YA., et al. 1998. Nature. 394: 377-81. PMID: 9690473
11. The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos.  |  McGrew, MJ., et al. 1998. Curr Biol. 8: 979-82. PMID: 9742402
12. Differential expression pattern of the three Fringe genes is associated with epidermal differentiation.  |  Thélu, J., et al. 1998. J Invest Dermatol. 111: 903-6. PMID: 9804358