MALT1 Antibody (clone 50): sc-130494
- MALT1 Antibody (clone 50) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against recombinant MALT1 of human origin
- recommended for detection of MALT1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See MALT1 (D-1): sc-515389 for MALT1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MALT1 Antibody (clone 50). This work is in progress.
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MALT1 Antibody (clone 50) is a mouse monoclonal IgG1 antibody that detects MALT1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MALT1, or mucosa-associated lymphoid tissue lymphoma translocation gene 1, plays a crucial role in the regulation of immune responses and is particularly significant in the context of B cell lymphomas, where MALT1 is often implicated in the pathogenesis of extranodal low-grade B cell lymphomas. MALT1 is located in the cytoplasm and interacts with several key signaling molecules, including Bcl10, which is essential for the oligomerization and activation of MALT1′s caspase-like domain. This interaction is vital for the activation of the NFκB signaling pathway, which promotes cell survival and proliferation, thereby contributing to the development of MALT lymphomas. The MALT1-API2 fusion protein, resulting from a common chromosomal translocation, further enhances this signaling cascade, leading to increased apoptosis inhibition and tumorigenesis. MALT1 mRNA expression is observed in pre-B cells, mature B cells, and plasma cells, highlighting MALT1′s importance in normal immune function and potential as a therapeutic target in lymphoid malignancies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MALT1 Antibody (clone 50) References:
- Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells. | Lork, M., et al. 2019. Cell Immunol. 340: 103877. PMID: 30514565
- MALT-1 as a novel therapeutic target for adult T-cell leukemia. | Ishikawa, C. and Mori, N. 2020. Eur J Haematol. 105: 460-467. PMID: 32574386
- MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies. | Liang, X., et al. 2021. Med Res Rev. 41: 2388-2422. PMID: 33763890
- MALT-1 inhibition attenuates the inflammatory response of ankylosing spondylitis by targeting NF-κB activation. | Qin, H., et al. 2021. Injury. 52: 1287-1293. PMID: 33827774
- The paracaspase MALT1 in psoriasis. | Hailfinger, S. and Schulze-Osthoff, K. 2021. Biol Chem. 402: 1583-1589. PMID: 34192836
- Targeting MALT1 for the treatment of diffuse large B-cell lymphoma. | Seshadri, MR. and Melnick, AM. 2022. Leuk Lymphoma. 63: 789-798. PMID: 34783281
- Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity. | Schmidt, H., et al. 2023. Proc Natl Acad Sci U S A. 120: e2309205120. PMID: 37988467
- Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells. | Yan, B., et al. 2023. Cell Death Discov. 9: 456. PMID: 38097554
- The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping. | Maghe, C., et al. 2024. Cell Rep. 43: 113631. PMID: 38183651
- MALT1 inhibition suppresses antigen-specific T cell responses. | Kerzeli, IK., et al. 2024. Cell Immunol. 397-398: 104814. PMID: 38422979
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MALT1 Antibody (clone 50) | sc-130494 | 200 µg/ml | $322.00 |