MALT1 Antibody (B-12): sc-46677

MALT1 Antibody (B-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects MALT1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MALT1 monoclonal antibody (B-12) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) plays a crucial role in the immune response, particularly in the activation of NFκB signaling pathways, which are essential for cell survival and proliferation. MALT1 is primarily located in the cytoplasm and is involved in the regulation of apoptosis and inflammation. This cytoplasmic localization allows MALT1 to interact with various signaling molecules, facilitating the transduction of signals that promote lymphocyte activation and differentiation. MALT1 (B-12) antibody is implicated in the pathogenesis of certain lymphomas, particularly those associated with the API2-MALT1 fusion protein, which results from chromosomal translocations. This fusion protein not only enhances the oncogenic potential of MALT1 but also disrupts normal apoptotic processes, leading to increased cell survival and proliferation in lymphoid tissues. MALT1 mRNA is expressed in pre-B cells, mature B cells, and plasma cells, highlighting MALT1′s importance in the development and function of the immune system.

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MALT1 Antibody (B-12) References:

1. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.  |  Dierlamm, J., et al. 1999. Blood. 93: 3601-9. PMID: 10339464
2. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.  |  Akagi, T., et al. 1999. Oncogene. 18: 5785-94. PMID: 10523859
3. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.  |  Uren, AG., et al. 2000. Mol Cell. 6: 961-7. PMID: 11090634
4. The API2/MALT1 fusion product may lead to germinal center B cell lymphomas by suppression of apoptosis.  |  Stoffel, A. and Le Beau, MM. 2001. Hum Hered. 51: 1-7. PMID: 11096264
5. API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.  |  Inagaki, H., et al. 2001. Am J Pathol. 158: 699-706. PMID: 11159207
6. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.  |  Lucas, PC., et al. 2001. J Biol Chem. 276: 19012-9. PMID: 11262391
7. T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10.  |  Liu, H., et al. 2001. Blood. 98: 1182-7. PMID: 11493468
8. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.  |  Xia, X., et al. 2020. J Clin Invest. 130: 5180-5196. PMID: 32831293
9. The Paracaspase MALT1 in Cancer.  |  Gomez Solsona, B., et al. 2022. Biomedicines. 10: PMID: 35203553
10. The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.  |  Kondreddy, V., et al. 2022. Blood. 140: 1549-1564. PMID: 35895897
11. Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas.  |  Wimberger, N., et al. 2023. Blood. 142: 1985-2001. PMID: 37623434
12. PRRSV utilizes MALT1-regulated autophagy flux to switch virus spread and reserve.  |  Gu, H., et al. 2024. Autophagy. 20: 2697-2718. PMID: 39081059

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MALT1 Antibody (B-12) has 41 citations in a variety of scientific publications.

Primary antibodies like Anti-MALT1 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MALT1 Antibody (B-12) Specifications

Alternate Product Name: Paracaspase MALT1

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 525-824

Epitope Target: MALT1

Epitope Species: human

Product Reactivity/Detection: MALT1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 41 citations in various scientific publications

Available Conjugates/Forms for MALT1 Antibody (B-12): AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790