MAGP-1 Antibody (E-3): sc-166076
- MAGP-1 Antibody (E-3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 32-61 near the N-terminus of MAGP-1 of human origin
- recommended for detection of MAGP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MAGP-1 Antibody (E-3) for WB applications. These reagents are now offered in bundles with MAGP-1 Antibody (E-3) (see ordering information below).
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MAGP-1 Antibody (E-3) is a mouse monoclonal IgG2b antibody that detects MAGP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAGP-1, or microfibril-associated glycoprotein 1, plays a crucial role in the formation and stabilization of elastic fibers, which are essential for the resilience and elasticity of various connective tissues. MAGP-1 is primarily located in the extracellular matrix, where MAGP-1 interacts with other key components such as fibrillin and elastin, forming a complex that is vital for maintaining the structural integrity of tissues. The proper assembly of these elastic fibers is critical for normal vascular development and function, as evidenced by studies showing that both underexpression and overexpression of the Zebrafish homolog of MAGP-1 significantly impact vascular morphology. Anti-MAGP-1 antibody (E-3) enables researchers to gain insights into the dynamics of elastic fiber formation and its implications in various physiological and pathological conditions, making MAGP-1 (E-3) antibody an invaluable tool for studies related to connective tissue disorders and vascular health.
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MAGP-1 Antibody (E-3) References:
- Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes. | Fujimoto, N., et al. 2000. Arch Dermatol Res. 292: 21-6. PMID: 10664011
- The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin. | Trask, BC., et al. 2000. Mol Biol Cell. 11: 1499-507. PMID: 10793130
- Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). | Trask, BC., et al. 2001. Biochemistry. 40: 4372-80. PMID: 11284693
- Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. | Jensen, SA., et al. 2001. J Biol Chem. 276: 39661-6. PMID: 11481325
- Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly. | Penner, AS., et al. 2002. J Biol Chem. 277: 35044-9. PMID: 12122015
- Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. | Miyamoto, A., et al. 2006. J Biol Chem. 281: 10089-97. PMID: 16492672
- Microfibril-associated glycoprotein-1 (MAGP-1) is specifically located on the beads of the beaded-filament structure for fibrillin-containing microfibrils as visualized by the rotary shadowing technique. | Henderson, M., et al. 1996. J Histochem Cytochem. 44: 1389-97. PMID: 8985131
- Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen. | Finnis, ML. and Gibson, MA. 1997. J Biol Chem. 272: 22817-23. PMID: 9278443
- Microfibril-associated glycoprotein-2 (MAGP-2) is specifically associated with fibrillin-containing microfibrils but exhibits more restricted patterns of tissue localization and developmental expression than its structural relative MAGP-1. | Gibson, MA., et al. 1998. J Histochem Cytochem. 46: 871-86. PMID: 9671438
- The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region. | Hatzinikolas, G. and Gibson, MA. 1998. J Biol Chem. 273: 29309-14. PMID: 9792630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAGP-1 Antibody (E-3) | sc-166076 | 200 µg/ml | $322.00 | |||
MAGP-1 Antibody (E-3): m-IgGκ BP-HRP Bundle | sc-534704 | 200 µg Ab; 40 µg BP | $361.00 | |||
MAGP-1 Antibody (E-3): m-IgG2b BP-HRP Bundle | sc-549284 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAGP-1 (E-3) Neutralizing Peptide | sc-166076 P | 100 µg/0.5 ml | $69.00 |