MAGP-1 Antibody (B-4): sc-166077
- MAGP-1 Antibody (B-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 32-61 near the N-terminus of MAGP-1 of human origin
- recommended for detection of MAGP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MAGP-1 Antibody (B-4) for WB applications. These reagents are now offered in bundles with MAGP-1 Antibody (B-4) (see ordering information below).
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MAGP-1 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects MAGP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAGP-1, or microfibril-associated glycoprotein 1, plays a crucial role in the formation and stabilization of elastic fibers, which are essential for the resilience and elasticity of various connective tissues. MAGP-1 is primarily located in the extracellular matrix, where MAGP-1 interacts with other key components such as fibrillin and elastin, forming a complex that is vital for maintaining the structural integrity of tissues. The proper assembly of these elastic fibers is critical for normal vascular development and function, as evidenced by studies showing that both underexpression and overexpression of the Zebrafish homolog of MAGP-1 significantly impact vascular morphology. Anti-MAGP-1 antibody (B-4) enables researchers to gain insights into the dynamics of elastic fiber formation and its implications in various physiological and pathological conditions, making MAGP-1 (B-4) antibody an invaluable tool for studies related to connective tissue disorders and vascular health.
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MAGP-1 Antibody (B-4) References:
- Microfibril-associated glycoprotein-2 specifically interacts with a range of bovine and human cell types via alphaVbeta3 integrin. | Gibson, MA., et al. 1999. J Biol Chem. 274: 13060-5. PMID: 10224057
- Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. | Werneck, CC., et al. 2004. J Biol Chem. 279: 23045-51. PMID: 15044481
- MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. | Hanssen, E., et al. 2004. J Biol Chem. 279: 29185-94. PMID: 15131124
- Microfibril-associated glycoprotein-1 and fibrillin-2 are associated with tropoelastin deposition in vitro. | Tsuruga, E., et al. 2005. Int J Biochem Cell Biol. 37: 120-9. PMID: 15381155
- The pattern of fibrillin deposition correlates with microfibril-associated glycoprotein 1 (MAGP-1) expression in cultured blood and lymphatic endothelial cells. | Weber, E., et al. 2004. Lymphology. 37: 116-26. PMID: 15560107
- Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly. | Cain, SA., et al. 2005. J Biol Chem. 280: 30526-37. PMID: 15980072
- Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. | Weinbaum, JS., et al. 2008. J Biol Chem. 283: 25533-25543. PMID: 18625713
- Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc. | Hayes, AJ., et al. 2011. Spine (Phila Pa 1976). 36: E1365-72. PMID: 21540769
- Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study. | Zheng, Q., et al. 2013. Clin Cosmet Investig Dermatol. 6: 317-23. PMID: 24353434
- Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25). | Gibson, MA., et al. 1996. J Biol Chem. 271: 1096-103. PMID: 8557636
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAGP-1 Antibody (B-4) | sc-166077 | 200 µg/ml | $322.00 | |||
MAGP-1 Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-537438 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAGP-1 Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-534705 | 200 µg Ab; 40 µg BP | $361.00 | |||
MAGP-1 Antibody (B-4): m-IgG1 BP-HRP Bundle | sc-545185 | 200 µg Ab; 20 µg BP | $361.00 | |||
MAGP-1 (B-4) Neutralizing Peptide | sc-166077 P | 100 µg/0.5 ml | $69.00 |