MAG Antibody (G-6): sc-373999

MAG Antibody (G-6) is a mouse monoclonal IgG2b antibody that detects myelin-associated glycoprotein (MAG) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAG is a crucial cell-surface adhesion protein in the nervous system, primarily located on the surface of myelinating glial cells, where MAG plays a vital role in linking these cells to neuronal axons. This interaction is essential for the maintenance of myelin integrity and the proper functioning of the nervous system. MAG′s presence on the surface of myelinating cells not only facilitates the formation of myelin sheaths but also contributes to the inhibitory environment that regulates axonal growth. Understanding MAG′s localization and function is important, as MAG′s inhibitory properties can impact neuronal regeneration and repair processes following injury. Furthermore, the modulation of MAG′s effects by neurotrophins such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) highlights MAG′s significance in neurobiology, as these factors can counteract MAG′s growth-inhibitory signals, potentially paving the way for therapeutic strategies in neurodegenerative diseases and nerve injuries. Anti-MAG antibody (G-6) is an invaluable tool for researchers investigating the complex interactions within the nervous system and the mechanisms underlying myelin-related pathologies.

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MAG Antibody (G-6) References:

1. Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin.  |  Schachner, M. and Bartsch, U. 2000. Glia. 29: 154-65. PMID: 10625334
2. Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions.  |  Marcus, J., et al. 2002. J Cell Biol. 156: 567-77. PMID: 11827985
3. Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways.  |  Palandri, A., et al. 2015. Cell Death Dis. 6: e1876. PMID: 26335717
4. Recombinant Human Myelin-Associated Glycoprotein Promoter Drives Selective AAV-Mediated Transgene Expression in Oligodendrocytes.  |  von Jonquieres, G., et al. 2016. Front Mol Neurosci. 9: 13. PMID: 26941604
5. Inhibition of neurite outgrowth using commercial myelin associated glycoprotein-Fc in neuro-2a cells.  |  Liu, F., et al. 2018. Neural Regen Res. 13: 1893-1899. PMID: 30233061
6. Detection and Characterization of Vesicular Gangliosides Binding to Myelin-Associated Glycoprotein on Supported Lipid Bilayers.  |  Cawley, JL., et al. 2021. Anal Chem. 93: 1185-1192. PMID: 33296186
7. Nerve ultrasound characteristics of immunoglobulin M neuropathy associated with anti-myelin-associated glycoprotein antibodies.  |  Oka, Y., et al. 2022. Muscle Nerve. 65: 667-675. PMID: 35353922
8. Vasculitic flare in a patient with anti-myelin-associated glycoprotein (MAG) antibody following mRNA-1273 SARS-CoV-2 vaccine.  |  Briani, C., et al. 2023. J Neurol. 270: 1207-1210. PMID: 36355184
9. Myelin-associated glycoprotein is not detectable in perikaryal myelin of spiral ganglion neurons of adult mice.  |  Martini, R. 1994. Glia. 10: 311-4. PMID: 7520024
10. Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein.  |  Bartsch, U. 1996. J Neurocytol. 25: 303-13. PMID: 8818975

The preferred MAG antibody is MAG Antibody (A-11): sc-166849.