MAdCAM-1 Antibody (MECA-89): sc-19605

MAdCAM-1 Antibody (MECA-89) is a rat monoclonal IgG2a antibody that detects MAdCAM-1 in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. MAdCAM-1, or mucosal addressin cell adhesion molecule 1, is a crucial immunoglobulin superfamily adhesion molecule that plays a significant role in the regulation of lymphocyte trafficking, particularly in mucosal tissues. MAdCAM-1 is predominantly expressed on the endothelium of mucosal venules, where MAdCAM-1 interacts with lymphocyte homing receptors such as L-Selectin and Integrin α4/β7, facilitating the migration of lymphocytes into Peyer′s patches and the intestinal lamina propria. This process is vital for maintaining immune surveillance and response in mucosal environments, as MAdCAM-1 ensures that lymphocytes are efficiently directed to sites where they are needed most. Furthermore, MAdCAM-1 is notably upregulated in conditions such as autoimmune-mediated liver disease, highlighting MAdCAM-1′s importance in inflammatory processes and potential as a therapeutic target. Anti-MAdCAM-1 antibody (MECA-89) is an essential tool for researchers studying lymphocyte dynamics and the underlying mechanisms of mucosal immunity.

The preferred MAdCAM-1 antibody is MAdCAM-1 Antibody (H-3): sc-365934.