MAdCAM-1 Antibody (MECA-367): sc-19604

MAdCAM-1 Antibody (MECA-367) is a rat monoclonal IgG2a antibody that detects MAdCAM-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). MAdCAM-1, or mucosal addressin cell adhesion molecule 1, plays a crucial role in the immune system by facilitating the homing of lymphocytes to mucosal tissues, which is essential for maintaining immune surveillance and response in these areas. MAdCAM-1 is primarily located on the endothelial cells of mucosal venules, where MAdCAM-1 interacts with specific leukocyte homing receptors, including L-Selectin and Integrin α4/β7, thereby directing lymphocyte migration into critical sites such as Peyer′s patches and the intestinal lamina propria. MAdCAM-1 expression is particularly heightened in inflammatory conditions, such as autoimmune-mediated liver disease, highlighting MAdCAM-1′s importance in the pathogenesis of chronic inflammatory disorders. Anti-MAdCAM-1 antibody (MECA-367) enables researchers to gain valuable insights into the mechanisms of lymphocyte trafficking and the role of this adhesion molecule in various immunological contexts.

The preferred MAdCAM-1 antibody is MAdCAM-1 Antibody (H-3): sc-365934.