Macrophage Subset Antibody (HIS36): sc-19612

Macrophage Subset Antibody (HIS36) is a mouse monoclonal IgG2a kappa light chain antibody that detects Macrophage Subset in mouse and rat tissues through immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Macrophage Subset (HIS36) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Macrophage Subset protein is crucial for immune response, as expression occurs on tissue macrophages and thioglycollate-elicited peritoneal exudate cells, playing a significant role in the innate immune system. These macrophages are essential for recognizing and engulfing pathogens, as targeting occurs for a wide range of bacterial invaders without prior exposure, thus acting as a first line of defense. The ability of macrophages to differentiate from circulating monocytes into tissue-resident cells allows adaptation to various microenvironments, enhancing phagocytic capabilities and promoting tissue homeostasis. Anti-Macrophage Subset antibody (HIS36) enables researchers to effectively study macrophage population dynamics in different tissues and responses to various stimuli, contributing to a deeper understanding of immune regulation and potential therapeutic targets in inflammatory diseases.

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Macrophage Subset Antibody (HIS36) References:

1. Aging and innate immune cells.  |  Plackett, TP., et al. 2004. J Leukoc Biol. 76: 291-9. PMID: 15039467
2. Chemokine receptors and leukocyte trafficking in the mucosal immune system.  |  Williams, IR. 2004. Immunol Res. 29: 283-92. PMID: 15181289
3. In vivo imaging of leukocyte trafficking in blood vessels and tissues.  |  Mempel, TR., et al. 2004. Curr Opin Immunol. 16: 406-17. PMID: 15245733
4. Interactions between the innate immune and blood coagulation systems.  |  Esmon, CT. 2004. Trends Immunol. 25: 536-42. PMID: 15364056
5. Chemokines: control of primary and memory T-cell traffic.  |  Schaerli, P. and Moser, B. 2005. Immunol Res. 31: 57-74. PMID: 15591623
6. Immune traffic: a functional overview.  |  Beilhack, A. and Rockson, SG. 2003. Lymphat Res Biol. 1: 219-34. PMID: 15624439
7. Leukocyte adhesion: what's the catch?  |  Hammer, DA. 2005. Curr Biol. 15: R96-9. PMID: 15694300
8. The macrophage as a secretory cell in chronic inflammation.  |  Davies, P. and Allison, AC. 1976. Agents Actions. 6: 60-74. PMID: 181971
9. Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset.  |  Huggins, DN., et al. 2021. Cancer Res. 81: 5284-5295. PMID: 34389631
10. Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury.  |  Yao, W., et al. 2022. Adv Sci (Weinh). 9: e2103675. PMID: 35112806
11. Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation.  |  Fabre, T., et al. 2023. Sci Immunol. 8: eadd8945. PMID: 37027478
12. A Galectin-9-Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia.  |  Li, Y., et al. 2024. Circulation. 149: 1670-1688. PMID: 38314577

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Macrophage Subset Antibody (HIS36) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Macrophage Subset Antibody (HIS36) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Macrophage Subset Antibody (HIS36) Specifications

Alternate Product Name: Macrophage Subset

Product Clone Name: HIS36

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Macrophage Subset

Epitope Species: rat

Product Reactivity/Detection: an ED2-like antigen, which is found on tissue macrophages and thioglycollated-elicited peritoneal exudate cells, by not on monocytes

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Macrophage Subset Antibody (HIS36): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin