M83 Antibody (B-5): sc-398790
- M83 Antibody (B-5) is a mouse monoclonal IgG2a κ M83 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 516-554 within an extracellular domain of M83 of human origin
- M83 Antibody (B-5) is recommended for detection of M83 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-M83 Antibody (B-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for M83 Antibody (B-5) for WB applications. These reagents are now offered in bundles with M83 Antibody (B-5) (see ordering information below).
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M83 Antibody (B-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects M83 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). M83 (B-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. M83, also known as TMEM8A (transmembrane protein 8A), is a 771 amino acid multi-pass membrane protein that plays a crucial role in cell surface adhesion, which is vital for maintaining cellular interactions and tissue integrity. As a member of the TMEM8 family, M83 is predominantly expressed in the spleen, liver, pancreas, placenta, tonsil, bone marrow, kidney, and peripheral blood leukocytes, highlighting its importance in immune function and tissue homeostasis. M83 contains one epidermal growth factor-like domain, which is significant for its role in maintaining T-cells in their resting state, thereby influencing immune responses. The gene encoding M83 is located on human chromosome 16, a region associated with various genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome, as well as Crohn′s disease, underscoring M83′s potential implications in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
M83 Antibody (B-5) References:
- Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. | Motohashi, T., et al. 2000. Biochem Biophys Res Commun. 276: 244-50. PMID: 11006113
- The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. | Bomont, P., et al. 2000. Nat Genet. 26: 370-4. PMID: 11062483
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. | Daniels, RJ., et al. 2001. Hum Mol Genet. 10: 339-52. PMID: 11157797
- Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene. | Kuhlenbäumer, G., et al. 2002. Neurology. 58: 1273-6. PMID: 11971098
- Genetics of inflammatory bowel disease: progress and prospects. | Mathew, CG. and Lewis, CM. 2004. Hum Mol Genet. 13 Spec No 1: R161-8. PMID: 14764625
- Advances in the genetics of inflammatory bowel disease. | Cho, JH. 2004. Curr Gastroenterol Rep. 6: 467-73. PMID: 15527676
- The Rubinstein-Taybi syndrome: occurrence in two sets of identical twins. | Baraitser, M. and Preece, MA. 1983. Clin Genet. 23: 318-20. PMID: 6682729
- Rubinstein-Taybi syndrome caused by submicroscopic deletions within 16p13.3. | Breuning, MH., et al. 1993. Am J Hum Genet. 52: 249-54. PMID: 8430691
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
M83 Antibody (B-5) | sc-398790 | 200 µg/ml | $316.00 | |||
M83 Antibody (B-5): m-IgG Fc BP-HRP Bundle | sc-530929 | 200 µg Ab; 10 µg BP | $354.00 | |||
M83 Antibody (B-5): m-IgGκ BP-HRP Bundle | sc-524487 | 200 µg Ab, 40 µg BP | $354.00 | |||
M83 Antibody (B-5): m-IgG2a BP-HRP Bundle | sc-547636 | 200 µg Ab; 10 µg BP | $354.00 | |||
M83 Antibody (B-5) AC | sc-398790 AC | 500 µg/ml, 25% agarose | $416.00 | |||
M83 Antibody (B-5) HRP | sc-398790 HRP | 200 µg/ml | $316.00 | |||
M83 Antibody (B-5) FITC | sc-398790 FITC | 200 µg/ml | $330.00 | |||
M83 Antibody (B-5) PE | sc-398790 PE | 200 µg/ml | $343.00 | |||
M83 Antibody (B-5) Alexa Fluor® 488 | sc-398790 AF488 | 200 µg/ml | $357.00 | |||
M83 Antibody (B-5) Alexa Fluor® 546 | sc-398790 AF546 | 200 µg/ml | $357.00 | |||
M83 Antibody (B-5) Alexa Fluor® 594 | sc-398790 AF594 | 200 µg/ml | $357.00 | |||
M83 Antibody (B-5) Alexa Fluor® 647 | sc-398790 AF647 | 200 µg/ml | $357.00 | |||
M83 Antibody (B-5) Alexa Fluor® 680 | sc-398790 AF680 | 200 µg/ml | $357.00 | |||
M83 Antibody (B-5) Alexa Fluor® 790 | sc-398790 AF790 | 200 µg/ml | $357.00 | |||
M83 (B-5) Neutralizing Peptide | sc-398790 P | 100 µg/0.5 ml | $68.00 |