LZIP Antibody (H-7): sc-515434
- LZIP Antibody (H-7) is a mouse monoclonal IgG1 κ LZIP antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 29-54 near the N-terminus of LZIP of mouse origin
- LZIP Antibody (H-7) is recommended for detection of LZIP of mouse origin by WB, IP, IF and ELISA
- Anti-LZIP Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-515434 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LZIP Antibody (H-7) for WB applications. These reagents are now offered in bundles with LZIP Antibody (H-7) (see ordering information below).
QUICK LINKS
SEE ALSO...
LZIP Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects LZIP protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LZIP antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LZIP protein, also known as Luman or CREB3, is a member of the ATF/CREB family and plays a crucial role in cellular processes by acting as a transcription factor that activates genes containing cyclic AMP response elements (CREs). LZIP function is particularly important in regulating gene expression in response to cellular stress and growth signals, thereby influencing cell proliferation and survival. LZIP is predominantly located in the endoplasmic reticulum, where LZIP interacts with HCF-1, a cellular protein essential for the activation of herpes simplex virus immediate-early genes. This interaction is vital for the transcriptional regulation of various genes, highlighting LZIP significance in both viral pathogenesis and normal cellular function. LZIP activity can be inhibited by HCLP-1, which underscores the complexity of LZIP regulatory mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LZIP Antibody (H-7) References:
- Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. | Zhou, HJ., et al. 2001. J Biol Chem. 276: 28933-8. PMID: 11384994
- Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis. | Raggo, C., et al. 2002. Mol Cell Biol. 22: 5639-49. PMID: 12138176
- Interaction of HCF-1 with a cellular nuclear export factor. | Mahajan, SS., et al. 2002. J Biol Chem. 277: 44292-9. PMID: 12235138
- Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. | Lu, R., et al. 1997. Mol Cell Biol. 17: 5117-26. PMID: 9271389
- The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF. | Lu, R., et al. 1998. J Virol. 72: 6291-7. PMID: 9658067
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LZIP Antibody (H-7) | sc-515434 | 200 µg/ml | $316.00 | |||
LZIP Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-531365 | 200 µg Ab; 10 µg BP | $354.00 | |||
LZIP Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-525037 | 200 µg Ab, 40 µg BP | $354.00 | |||
LZIP Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-544506 | 200 µg Ab; 20 µg BP | $354.00 | |||
LZIP Antibody (H-7) X | sc-515434 X | 200 µg/0.1 ml | $316.00 | |||
LZIP Antibody (H-7) AC | sc-515434 AC | 500 µg/ml, 25% agarose | $416.00 | |||
LZIP Antibody (H-7) HRP | sc-515434 HRP | 200 µg/ml | $316.00 | |||
LZIP Antibody (H-7) FITC | sc-515434 FITC | 200 µg/ml | $330.00 | |||
LZIP Antibody (H-7) PE | sc-515434 PE | 200 µg/ml | $343.00 | |||
LZIP Antibody (H-7) Alexa Fluor® 488 | sc-515434 AF488 | 200 µg/ml | $357.00 | |||
LZIP Antibody (H-7) Alexa Fluor® 546 | sc-515434 AF546 | 200 µg/ml | $357.00 | |||
LZIP Antibody (H-7) Alexa Fluor® 594 | sc-515434 AF594 | 200 µg/ml | $357.00 | |||
LZIP Antibody (H-7) Alexa Fluor® 647 | sc-515434 AF647 | 200 µg/ml | $357.00 | |||
LZIP Antibody (H-7) Alexa Fluor® 680 | sc-515434 AF680 | 200 µg/ml | $357.00 | |||
LZIP Antibody (H-7) Alexa Fluor® 790 | sc-515434 AF790 | 200 µg/ml | $357.00 | |||
LZIP (H-7) Neutralizing Peptide | sc-515434 P | 100 µg/0.5 ml | $68.00 |