LysRS Antibody (D-4): sc-393645

LysRS Antibody (D-4) is a mouse monoclonal IgG3 antibody that detects LysRS in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LysRS, or lysyl-tRNA synthetase, plays a crucial role in protein synthesis by catalyzing the attachment of lysine to its corresponding tRNA, ensuring the accurate translation of genetic information into functional proteins. This process is vital for cellular function and growth, as any errors in amino acid incorporation can lead to dysfunctional proteins and contribute to various diseases. Notably, LysRS exists in both mitochondrial and cytoplasmic isoforms, with the mitochondrial variant being 625 amino acids long and the cytoplasmic variant comprising 576 amino acids. The presence of these isoforms highlights LysRS′s versatility and importance in different cellular contexts. Furthermore, LysRS has been implicated in autoimmune diseases such as polymyositis and dermatomyositis, making LysRS a significant target for research in understanding these conditions. The gene encoding LysRS is located on human chromosome 16, which is known for its dense gene content, comprising over 900 genes and nearly 3% of the human genome, underscoring the complexity and importance of LysRS in human health and disease.

The preferred LysRS antibody is LysRS Antibody (A-10): sc-271331.