Ly-49I Antibody (YLI-90): sc-53024

Ly-49I Antibody (YLI-90) is a mouse monoclonal IgG1 antibody that detects Ly-49I in mouse samples through flow cytometry (FCM). Ly-49I is a member of the Ly-49 family of receptors, which are critical for the regulation of natural killer (NK) cell activity. These receptors play a vital role in the immune response by recognizing and binding to specific ligands on target cells, thereby influencing NK cell activation and inhibition. The structure of Ly-49I contains a C-type lectin-like domain that facilitates interaction with MHC class I molecules, allowing NK cells to distinguish between healthy and stressed or infected cells. This ability to recognize altered self-cells is crucial for maintaining immune surveillance and preventing tumor proliferation. Ly-49I is predominantly expressed on the surface of NK cells, where Ly-49I contributes to the balance of activating and inhibitory signals that dictate NK cell responses. Using anti-Ly-49I antibody (YLI-90) in research can provide valuable insights into NK cell regulation mechanisms and their implications in immunological disorders and cancer biology.

The preferred Ly-49 antibody is Ly-49 Antibody (14B11): sc-53022.