Ly-49I Antibody (5K29): sc-71523
- Ly-49I Antibody (5K29) is a mouse monoclonal IgG1 κ Ly-49I antibody provided at 200 µg/ml
- raised against the B6 allele of Ly-49I of mouse origin
- recommended for detection of Ly-49I of mouse origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Ly-49I Antibody (5K29). This reagent is now offered in a bundle with Ly-49I Antibody (5K29) (see ordering information below).
Ly-49I Antibody (5K29) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ly-49I protein of mouse origin by flow cytometry (FCM). anti-Ly-49I antibody (5K29) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC), providing flexibility for different experimental needs. Ly-49I protein plays a crucial role in regulating natural killer (NK) cell activity, which is essential for immune response against tumors and virally infected cells. Specifically, Ly-49I is a member of the C-type lectin superfamily of type II membrane glycoproteins, which are involved in recognizing class I major histocompatibility complex (MHC) molecules. This interaction helps NK cells distinguish between healthy and abnormal cells, thereby preventing potentially harmful cell proliferation. The Ly-49 family consists of at least 21 isoforms, each varying in length from 230 to 280 amino acids, clustered on human chromosome 16. These isoforms can form homodimers on the cell surface, enhancing their ability to mediate inhibitory signals that regulate NK cell activity. Understanding Ly-49I function and interactions is important for developing therapeutic strategies that harness immune system′s power against cancer and other diseases.
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Ly-49I Antibody (5K29) References:
- Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset. | Naper, C., et al. 1999. Eur J Immunol. 29: 2046-53. PMID: 10382768
- Levels of Ly-49 receptor expression are determined by the frequency of interactions with MHC ligands: evidence against receptor calibration to a 'useful' level. | Manilay, JO., et al. 1999. J Immunol. 163: 2628-33. PMID: 10453002
- Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. | Coles, MC., et al. 2000. Eur J Immunol. 30: 236-44. PMID: 10602046
- Positive and negative roles of the trans-acting T cell factor-1 for the acquisition of distinct Ly-49 MHC class I receptors by NK cells. | Kunz, B. and Held, W. 2001. J Immunol. 166: 6181-7. PMID: 11342639
- Specificity and function of activating Ly-49 receptors. | Kane, KP., et al. 2001. Immunol Rev. 181: 104-14. PMID: 11513132
- Ly-49 receptors and their functions. | Kane, KP., et al. 2004. Crit Rev Immunol. 24: 321-48. PMID: 15663362
- In search of the 'missing self': MHC molecules and NK cell recognition. | Ljunggren, HG. and Kärre, K. 1990. Immunol Today. 11: 237-44. PMID: 2201309
- The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. | Ortaldo, JR., et al. 1998. J Immunol. 160: 1158-65. PMID: 9570529
- Developmentally regulated extinction of Ly-49 receptor expression permits maturation and selection of NK1.1+ T cells. | Robson MacDonald, H., et al. 1998. J Exp Med. 187: 2109-14. PMID: 9625772
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ly-49I Antibody (5K29) | sc-71523 | 200 µg/ml | $322.00 | |||
Ly-49I Antibody (5K29): m-IgG Fc BP-HRP Bundle | sc-539373 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ly-49I Antibody (5K29) FITC | sc-71523 FITC | 200 µg/ml | $336.00 | |||
Ly-49I Antibody (5K29) PE | sc-71523 PE | 200 µg/ml | $349.00 |