Lutropin β Antibody (C-6): sc-373941

Lutropin β Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Lutropin beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Lutropin beta antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Lutropin beta protein, also known as luteinizing hormone (LH), plays a vital role in reproductive health by regulating spermatogenesis in males and ovulation in females through stimulation of steroid hormone production in testes and ovaries. LH′s structure as a heterodimer consists of a common alpha chain and a unique beta chain, enabling specific receptor interactions and biological activity. LH exists in various isoforms through proteolytic processing, influencing stability and function in circulation. Understanding Lutropin beta′s structural characteristics helps reveal hormonal signaling mechanisms and reproductive disorder implications, making Lutropin beta monoclonal antibody (C-6) an essential research tool for studying these biological processes.

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Lutropin β Antibody (C-6) References:

1. Evolution of lutropin to chorionic gonadotropin generates a specific routing signal for apical release in vivo.  |  Jablonka-Shariff, A., et al. 2002. J Biol Chem. 277: 879-82. PMID: 11723109
2. Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexes.  |  Xing, Y., et al. 2004. J Biol Chem. 279: 44427-37. PMID: 15304492
3. Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor.  |  Bernard, MP., et al. 2004. J Biol Chem. 279: 44438-41. PMID: 15304512
4. The beta subunits of glycoprotein hormones. Formation of three-dimensional structure during cell-free biosynthesis of lutropin-beta.  |  Strickland, TW. and Pierce, JG. 1985. J Biol Chem. 260: 5816-9. PMID: 2580840
5. A receptor-binding region in human choriogonadotropin/lutropin beta subunit.  |  Keutmann, HT., et al. 1987. Proc Natl Acad Sci U S A. 84: 2038-42. PMID: 3470775
6. Structural analysis of N-linked oligosaccharides of equine chorionic gonadotropin and lutropin beta-subunits.  |  Matsui, T., et al. 1994. Biochemistry. 33: 14039-48. PMID: 7524670
7. The control of gonadotrophin secretion by ovarian steroids.  |  Couzinet, B. and Schaison, G. 1993. Hum Reprod. 8 Suppl 2: 97-101. PMID: 8276977
8. Metabolism of hCG and hLH to multiple urinary forms.  |  Birken, S., et al. 1996. Mol Cell Endocrinol. 125: 121-31. PMID: 9027350
9. Characterization and phylogenetic significance of rhinoceros luteinizing hormone beta (LHbeta) subunit messenger RNA structure, complementary DNA sequence and gene copy number.  |  Sherman, GB., et al. 1997. Gene. 195: 131-9. PMID: 9305757
10. The human follitropin alpha-subunit C terminus collaborates with a beta-subunit cystine noose and an alpha-subunit loop to assemble a receptor-binding domain competent for signal transduction.  |  Arnold, CJ., et al. 1998. Biochemistry. 37: 1762-8. PMID: 9485301
11. Dissociation of early folding events from assembly of the human lutropin beta-subunit.  |  Muyan, M., et al. 1998. Mol Endocrinol. 12: 1640-9. PMID: 9773985
12. Recombinant forms of rat and human luteinizing hormone and follicle-stimulating hormone; comparison of functions in vitro and in vivo.  |  Hakola, K., et al. 1998. J Endocrinol. 158: 441-8. PMID: 9846174

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Lutropin β Antibody (C-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Lutropin β Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Lutropin β Antibody (C-6) Specifications

Alternate Product Name: Lutropin β

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 109-135

Epitope Target: Lutropin β

Epitope Species: rat

Product Reactivity/Detection: Lutropin β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Lutropin β Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin