Lumican Antibody (B-9): sc-166871
- Lumican Antibody (B-9) is a mouse monoclonal IgG1 κ Lumican antibody, cited in 20 publications, provided at 200 µg/ml
- raised against amino acids 19-108 mapping near the N-terminus of Lumican of human origin
- Lumican Antibody (B-9) is recommended for detection of precursor and mature Lumican of human origin by WB, IP, IF and ELISA
- Anti-Lumican Antibody (B-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Lumican Antibody (B-9) for WB applications. These reagents are now offered in bundles with Lumican Antibody (B-9) (see ordering information below).
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Lumican Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Lumican protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Lumican (B-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Lumican, a member of the small leucine-rich proteoglycans (SLRPs) family, plays a crucial role in regulating collagen fibrillogenesis, which is essential for maintaining structural integrity of tissues. Lumican is predominantly found in corneal stroma and interstitial matrices of various tissues, including heart, aorta, skeletal muscle, skin, and intervertebral discs. Lumican′s ability to modulate collagen assembly into higher-order fibrils is vital for controlling diameter of these fibrils, thereby influencing tissue strength and elasticity. Notably, Lumican is present in extracellular matrix of human articular cartilage throughout life, with significantly higher levels observed in adults, indicating importance in cartilage health and function. Human Lumican gene is located on chromosome 12q21.3-q22, highlighting genetic significance in various physiological and pathological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Lumican Antibody (B-9) References:
- A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice. | Jepsen, KJ., et al. 2002. J Biol Chem. 277: 35532-40. PMID: 12089156
- Roles of lumican and keratocan on corneal transparency. | Kao, WW. and Liu, CY. 2002. Glycoconj J. 19: 275-85. PMID: 12975606
- Functions of lumican and fibromodulin: lessons from knockout mice. | Chakravarti, S. 2002. Glycoconj J. 19: 287-93. PMID: 12975607
- Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling. | Vij, N., et al. 2005. Invest Ophthalmol Vis Sci. 46: 88-95. PMID: 15623759
- Lumican as a multivalent effector in wound healing. | Karamanou, K., et al. 2018. Adv Drug Deliv Rev. 129: 344-351. PMID: 29501701
- Lumican in Carcinogenesis-Revisited. | Giatagana, EM., et al. 2021. Biomolecules. 11: PMID: 34572532
- Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy. | Rixon, C., et al. 2023. ESC Heart Fail. 10: 858-871. PMID: 36444917
- Circulating lumican as a potential biomarker for osteosarcopenia in older adults. | Park, SJ., et al. 2024. Bone. 179: 116959. PMID: 37956822
- Lumican promotes calcific aortic valve disease through H3 histone lactylation. | Huang, Y., et al. 2024. Eur Heart J. 45: 3871-3885. PMID: 38976370
- Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. | Chakravarti, S., et al. 1995. Genomics. 27: 481-8. PMID: 7558030
- Localization of mouse lumican (keratan sulfate proteoglycan) to distal chromosome 10. | Chakravarti, S. and Magnuson, T. 1995. Mamm Genome. 6: 367-8. PMID: 7626890
- The human lumican gene. Organization, chromosomal location, and expression in articular cartilage. | Grover, J., et al. 1995. J Biol Chem. 270: 21942-9. PMID: 7665616
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lumican Antibody (B-9) | sc-166871 | 200 µg/ml | $316.00 | |||
Lumican Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-529075 | 200 µg Ab; 10 µg BP | $354.00 | |||
Lumican Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-521780 | 200 µg Ab, 40 µg BP | $354.00 | |||
Lumican Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-543305 | 200 µg Ab; 20 µg BP | $354.00 | |||
Lumican Antibody (B-9) AC | sc-166871 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Lumican Antibody (B-9) HRP | sc-166871 HRP | 200 µg/ml | $316.00 | |||
Lumican Antibody (B-9) FITC | sc-166871 FITC | 200 µg/ml | $330.00 | |||
Lumican Antibody (B-9) PE | sc-166871 PE | 200 µg/ml | $343.00 | |||
Lumican Antibody (B-9) Alexa Fluor® 488 | sc-166871 AF488 | 200 µg/ml | $357.00 | |||
Lumican Antibody (B-9) Alexa Fluor® 546 | sc-166871 AF546 | 200 µg/ml | $357.00 | |||
Lumican Antibody (B-9) Alexa Fluor® 594 | sc-166871 AF594 | 200 µg/ml | $357.00 | |||
Lumican Antibody (B-9) Alexa Fluor® 647 | sc-166871 AF647 | 200 µg/ml | $357.00 | |||
Lumican Antibody (B-9) Alexa Fluor® 680 | sc-166871 AF680 | 200 µg/ml | $357.00 | |||
Lumican Antibody (B-9) Alexa Fluor® 790 | sc-166871 AF790 | 200 µg/ml | $357.00 |