LTβR Antibody (H-2): sc-398929

LTβR Antibody (H-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects LTβR of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LTβR antibody (H-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LTβR plays a crucial role in the immune system, particularly in lymphoid organ development and the regulation of immune responses. LTβR is activated upon binding with the heterotrimeric lymphotoxin LT-α1/β2, which triggers downstream signaling pathways, including NFκB activation, leading to cellular responses such as apoptosis and inflammation. LTβR is expressed on the surface of most cell types, excluding T and B lymphocytes, highlighting its importance in mediating interactions between immune cells and the lymphoid microenvironment. Understanding LTβR function is essential for elucidating its role in immune regulation and potential implications in therapeutic strategies for immune-related diseases.

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LTβR Antibody (H-2) References:

1. Suppression of established experimental autoimmune encephalomyelitis and formation of meningeal lymphoid follicles by lymphotoxin beta receptor-Ig fusion protein.  |  Columba-Cabezas, S., et al. 2006. J Neuroimmunol. 179: 76-86. PMID: 16870269
2. Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure.  |  Lee, Y., et al. 2006. Immunity. 25: 499-509. PMID: 16934497
3. Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy.  |  Lukashev, M., et al. 2006. Cancer Res. 66: 9617-24. PMID: 17018619
4. Inhibition of LTβR signalling activates WNT-induced regeneration in lung.  |  Conlon, TM., et al. 2020. Nature. 588: 151-156. PMID: 33149305
5. LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation.  |  Gupta, RK., et al. 2024. J Autoimmun. 144: 103177. PMID: 38368767
6. LTβR Agonism Promotes Antitumor Immune Responses via Modulation of the Tumor Microenvironment.  |  An, D., et al. 2024. Cancer Res. 84: 3984-4001. PMID: 39137402
7. The Fas death factor.  |  Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
8. The ligands and receptors of the lymphotoxin system.  |  Ware, CF., et al. 1995. Curr Top Microbiol Immunol. 198: 175-218. PMID: 7774281
9. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
10. A lymphotoxin-beta-specific receptor.  |  Crowe, PD., et al. 1994. Science. 264: 707-10. PMID: 8171323
11. Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.  |  VanArsdale, TL., et al. 1997. Proc Natl Acad Sci U S A. 94: 2460-5. PMID: 9122217
12. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues.  |  Fütterer, A., et al. 1998. Immunity. 9: 59-70. PMID: 9697836

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LTβR Antibody (H-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LTβR Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LTβR Antibody (H-2) Specifications

Alternate Product Name: LTβR

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 41-150

Epitope Target: LTβR

Epitope Species: mouse

Product Reactivity/Detection: LTβR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LTβR Antibody (H-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin