LSECtin Antibody (SOTO-1): sc-65478

LSECtin Antibody (SOTO-1) is a mouse monoclonal IgG2a λ light chain antibody that detects human LSECtin by immunoprecipitation (IP) and flow cytometry (FCM). LSECtin monoclonal antibody (SOTO-1) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Liver and lymph node Sinusoidal Endothelial C-type lectin (LSECtin), also known as C-type lectin superfamily 4 member G (CLEC4G), functions as a type II transmembrane glycoprotein in the immune system. LSECtin is primarily expressed on liver sinusoidal endothelial cells, functioning as a lectin receptor that binds specific carbohydrates including mannose, N-acetylglucosamine, and L-fucose in a calcium-dependent manner. This binding capability enables LSECtin to serve as an attachment factor for viral pathogens, potentially concentrating them in lymph nodes and liver - critical sites for immune response initiation. LSECtin gene resides within a gene cluster containing CD23, DC-SIGN, and DC-SIGNR on chromosome 19p13.2, highlighting its evolutionary relationship with other immune receptors.

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LSECtin Antibody (SOTO-1) References:

1. Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.  |  Liu, W., et al. 2004. J Biol Chem. 279: 18748-58. PMID: 14711836
2. Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation.  |  Koppel, EA., et al. 2005. Cell Microbiol. 7: 157-65. PMID: 15659060
3. LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus.  |  Gramberg, T., et al. 2005. Virology. 340: 224-36. PMID: 16051304
4. How the SARS coronavirus causes disease: host or organism?  |  Lo, AW., et al. 2006. J Pathol. 208: 142-51. PMID: 16362992
5. Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses.  |  Dakappagari, N., et al. 2006. J Immunol. 176: 426-40. PMID: 16365436
6. Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor.  |  Kuhn, JH., et al. 2006. J Biol Chem. 281: 15951-8. PMID: 16595665
7. Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins.  |  Powlesland, AS., et al. 2006. J Biol Chem. 281: 20440-9. PMID: 16682406
8. [Preparation and characterization of monoclonal antibody against human LSECtin].  |  Du, XM., et al. 2006. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 22: 517-20. PMID: 16806021
9. The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells.  |  Dominguez-Soto, A., et al. 2007. Blood. 109: 5337-45. PMID: 17339424

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LSECtin Antibody (SOTO-1) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-LSECtin Antibody (SOTO-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LSECtin Antibody (SOTO-1) Specifications

Alternate Product Name: LSECtin

Product Clone Name: SOTO-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a lambda light chain

Amino Acids:

Epitope Target: LSECtin

Epitope Species: human

Product Reactivity/Detection: LSECtin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, FCM

Vialing Information: Each vial contains 200 µg IgG_2a lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for LSECtin Antibody (SOTO-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin