LRRC8D Antibody (A-12): sc-515070
- LRRC8D Antibody (A-12) is a mouse monoclonal IgG1 κ LRRC8D antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 221-282 mapping within an internal region of LRRC8D of human origin
- LRRC8D Antibody (A-12) is recommended for detection of LRRC8D of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LRRC8D Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for LRRC8D Antibody (A-12) for WB applications. These reagents are now offered in bundles with LRRC8D Antibody (A-12) (see ordering information below).
LRRC8D Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects LRRC8D protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRRC8D (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LRRC8D protein, also known as leucine-rich repeat-containing protein 8D, is a multi-pass membrane protein consisting of 858 amino acids and features thirteen leucine-rich repeats (LRRs). LRRs are critical for LRRC8D protein′s function, as these repeats facilitate protein-protein interactions essential for various cellular processes, including those involved in innate immunity and nervous system development. LRRs allow LRRC8D to adopt a versatile structural framework, which is vital for forming complexes with other proteins. Mutations in genes encoding LRR-containing proteins, such as LRRC8D, have been linked to several human diseases, underscoring LRRC8D′s significance in maintaining cellular homeostasis and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRRC8D Antibody (A-12) References:
- Molecular cloning of a novel membrane glycoprotein, pal, specifically expressed in photoreceptor cells of the retina and containing leucine-rich repeat. | Gomi, F., et al. 2000. J Neurosci. 20: 3206-13. PMID: 10777785
- Lack of blood-brain barrier properties in microvessels of the prelaminar optic nerve head. | Hofman, P., et al. 2001. Invest Ophthalmol Vis Sci. 42: 895-901. PMID: 11274064
- The leucine-rich repeat as a protein recognition motif. | Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
- Vascular leucocyte adhesion molecules unaltered in the human retina in diabetes. | Hughes, JM., et al. 2004. Br J Ophthalmol. 88: 566-72. PMID: 15031178
- Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. | Kuiper, EJ., et al. 2004. Br J Ophthalmol. 88: 1082-7. PMID: 15258030
- Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. | Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
- Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation. | Nakamura, R., et al. 2020. Commun Biol. 3: 240. PMID: 32415200
- Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy. | Widmer, CA., et al. 2022. Cancer Res Commun. 2: 1266-1281. PMID: 36467895
- Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly. | Takahashi, H., et al. 2023. Elife. 12: PMID: 36897307
- A target discovery pipeline identified ILT3 as a target for immunotherapy of multiple myeloma. | Di Meo, F., et al. 2023. Cell Rep Med. 4: 101110. PMID: 37467717
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRRC8D Antibody (A-12) | sc-515070 | 200 µg/ml | $322.00 | |||
LRRC8D Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-527976 | 200 µg Ab; 10 µg BP | $361.00 | |||
LRRC8D Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-533349 | 200 µg Ab; 20 µg BP | $361.00 | |||
LRRC8D Antibody (A-12) AC | sc-515070 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LRRC8D Antibody (A-12) HRP | sc-515070 HRP | 200 µg/ml | $322.00 | |||
LRRC8D Antibody (A-12) FITC | sc-515070 FITC | 200 µg/ml | $336.00 | |||
LRRC8D Antibody (A-12) PE | sc-515070 PE | 200 µg/ml | $349.00 | |||
LRRC8D Antibody (A-12) Alexa Fluor® 488 | sc-515070 AF488 | 200 µg/ml | $364.00 | |||
LRRC8D Antibody (A-12) Alexa Fluor® 546 | sc-515070 AF546 | 200 µg/ml | $364.00 | |||
LRRC8D Antibody (A-12) Alexa Fluor® 594 | sc-515070 AF594 | 200 µg/ml | $364.00 | |||
LRRC8D Antibody (A-12) Alexa Fluor® 647 | sc-515070 AF647 | 200 µg/ml | $364.00 | |||
LRRC8D Antibody (A-12) Alexa Fluor® 680 | sc-515070 AF680 | 200 µg/ml | $364.00 | |||
LRRC8D Antibody (A-12) Alexa Fluor® 790 | sc-515070 AF790 | 200 µg/ml | $364.00 |