LRRC8A Antibody (8H9): sc-517113

LRRC8A Antibody (8H9) is a mouse monoclonal IgG2a kappa light chain antibody that detects LRRC8A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-LRRC8A antibody (8H9) is available as a non-conjugated format. LRRC8A protein plays a crucial role in forming volume-regulated anion channels, which are essential for maintaining cellular homeostasis and regulating cell volume under osmotic stress. These channels are vital for various physiological processes, including cell proliferation, apoptosis, and ion transport regulation, making them significant in both normal cellular function and disease states. Dysregulation of LRRC8A has been implicated in several pathologies, including cancer and neurological disorders, highlighting the importance of studying LRRC8A for potential therapeutic interventions. Additionally, chromosome 9, where the LRRC8A gene is located, is known for its involvement in various genetic conditions and diseases, further emphasizing the relevance of LRRC8A monoclonal antibody (8H9) in research and clinical applications.

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LRRC8A Antibody (8H9) References:

1. Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome.  |  Horibata, K., et al. 2004. Proc Natl Acad Sci U S A. 101: 15410-5. PMID: 15486090
2. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
3. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
4. PTEN hamartoma tumor syndromes.  |  Blumenthal, GM. and Dennis, PA. 2008. Eur J Hum Genet. 16: 1289-300. PMID: 18781191
5. PTEN: a new guardian of the genome.  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
6. Kabuki syndrome and trisomy 10p.  |  Utine, GE., et al. 2008. Genet Couns. 19: 291-300. PMID: 18990985
7. Apparent late-onset Cockayne syndrome and interstitial deletion of the long arm of chromosome 10 (del(10)(q11.23q21.2)).  |  Fryns, JP., et al. 1991. Am J Med Genet. 40: 343-4. PMID: 1951442
8. Chromosomal location of two human genes encoding tetrahydrobiopterin-metabolizing enzymes: 6-pyruvoyl-tetrahydropterin synthase maps to 11q22.3-q23.3, and pterin-4 alpha-carbinolamine dehydratase maps to 10q22.  |  Thöny, B., et al. 1994. Genomics. 19: 365-8. PMID: 8188266

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRRC8A Antibody (8H9) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-LRRC8A Antibody (8H9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRRC8A Antibody (8H9) Specifications

Alternate Product Name: LRRC8A

Product Clone Name: 8H9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 711-810

Epitope Target: LRRC8A

Epitope Species: human

Product Reactivity/Detection: LRRC8A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for LRRC8A Antibody (8H9): N/A