LRP130 Antibody (G-10): sc-166177
- LRP130 Antibody (G-10) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 974-1273 mapping at the C-terminus of LRP130 of human origin
- recommended for detection of LRP130 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-166177 X, 200 µg/0.1 ml)
- See LRP130 (F-7): sc-166178 for LRP130 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for LRP130 Antibody (G-10) for WB and IHC(P) applications. These reagents are now offered in bundles with LRP130 Antibody (G-10) (see ordering information below).
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SEE ALSO...
LRP130 Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects LRP130 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). LRP130, also known as leucine-rich pentatricopeptide repeat-containing protein, plays a crucial role in regulating mitochondrial gene expression by binding to mRNA and facilitating processing, which is essential for proper mitochondrial function and energy production. LRP130′s localization in the cytoplasm enables interaction with mitochondrial transcripts, ensuring necessary proteins for mitochondrial biogenesis and function are synthesized efficiently. Defects in the LRPPRC gene, which encodes LRP130, can lead to severe neurological disorders such as the French-Canadian type of Leigh syndrome, highlighting LRP130′s significance in maintaining cellular health and function. Additionally, LRP130′s interaction with the low-affinity receptor for leukemia inhibitory factor underscores its role in intracellular signaling pathways, further emphasizing LRP130′s importance in cellular communication and response mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRP130 Antibody (G-10) References:
- Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA. | Mili, S., et al. 2001. Mol Cell Biol. 21: 7307-19. PMID: 11585913
- LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1. | Tsuchiya, N., et al. 2002. Eur J Biochem. 269: 2927-33. PMID: 12071956
- LRP130, a pentatricopeptide motif protein with a noncanonical RNA-binding domain, is bound in vivo to mitochondrial and nuclear RNAs. | Mili, S. and Piñol-Roma, S. 2003. Mol Cell Biol. 23: 4972-82. PMID: 12832482
- Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. | Cooper, MP., et al. 2008. J Biol Chem. 283: 31960-7. PMID: 18728005
- Leucine-rich protein 130 contributes to apoptosis resistance of human hepatocarcinoma cells. | Michaud, M., et al. 2011. Int J Oncol. 38: 169-78. PMID: 21109938
- LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. | Liu, L., et al. 2011. J Biol Chem. 286: 41253-41264. PMID: 21971050
- Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/PGC-1α Complex in Aged Rats. | Vechetti-Junior, IJ., et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 601-9. PMID: 25991827
- The effect of acute and chronic sprint-interval training on LRP130, SIRT3, and PGC-1α expression in human skeletal muscle. | Edgett, BA., et al. 2016. Physiol Rep. 4: PMID: 27604398
- Fiber-specific and whole-muscle LRP130 expression in rested, exercised, and fasted human skeletal muscle. | Islam, H., et al. 2020. Pflugers Arch. 472: 375-384. PMID: 32065259
- LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis. | Sun, X., et al. 2020. EMBO Rep. 21: e48796. PMID: 32149459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRP130 Antibody (G-10) | sc-166177 | 200 µg/ml | $316.00 | |||
LRP130 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-540037 | 200 µg Ab; 10 µg BP | $354.00 | |||
LRP130 Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-541862 | 200 µg Ab; 20 µg BP | $354.00 | |||
LRP130 Antibody (G-10) X | sc-166177 X | 200 µg/0.1 ml | $316.00 |