LRP130 Antibody (F-7): sc-166178

LRP130 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects LRP130 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). LRP130 (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The leucine-rich repeat (LRR) motif, which is a key structural feature of LRP130, consists of 20-30 amino acids that form a hydrophobic α/β horseshoe fold, allowing LRP130 to effectively accommodate several leucine residues within a tightly packed core. This unique structure is crucial for LRP130′s function as a cytoplasmic mRNA-binding protein, which plays a significant role in the processing of mitochondrial DNA transcripts. Defects in the LRPPRC gene that encodes LRP130 are linked to the French-Canadian type of Leigh syndrome, a severe neurological disorder characterized by lesions in the subcortical region of the brain, highlighting LRP130′s critical role in cellular health and function. LRP130 interacts with the low-affinity receptor for leukemia inhibitory factor, initiating an intracellular signaling cascade that further underscores LRP130′s importance in cellular communication and response mechanisms.

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LRP130 Antibody (F-7) References:

1. The leucine-rich repeat as a protein recognition motif.  |  Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
2. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity.  |  Liu, L. and McKeehan, WL. 2002. Genomics. 79: 124-36. PMID: 11827465
3. LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo.  |  Tsuchiya, N., et al. 2004. Biochem Biophys Res Commun. 317: 736-43. PMID: 15081402
4. The role of the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome c oxidase) I and COX III mRNA.  |  Xu, F., et al. 2004. Biochem J. 382: 331-6. PMID: 15139850
5. New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein.  |  Labialle, S., et al. 2004. Nucleic Acids Res. 32: 3864-76. PMID: 15272088
6. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.  |  Cooper, MP., et al. 2006. Genes Dev. 20: 2996-3009. PMID: 17050673
7. Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer.  |  Yang, Y., et al. 2022. Cell Death Differ. 29: 2177-2189. PMID: 35484333
8. The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer.  |  Zhou, W., et al. 2023. Nat Commun. 14: 4212. PMID: 37452037
9. Proteins with leucine-rich repeats.  |  Kobe, B. and Deisenhofer, J. 1995. Curr Opin Struct Biol. 5: 409-16. PMID: 7583641
10. The leucine-rich repeat: a versatile binding motif.  |  Kobe, B. and Deisenhofer, J. 1994. Trends Biochem Sci. 19: 415-21. PMID: 7817399
11. Molecular cloning and expression of the gene for a major leucine-rich protein from human hepatoblastoma cells (HepG2).  |  Hou, J., et al. 1994. In Vitro Cell Dev Biol Anim. 30A: 111-4. PMID: 8012652

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRP130 Antibody (F-7) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-LRP130 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRP130 Antibody (F-7) Specifications

Alternate Product Name: LRP130

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 974-1273

Epitope Target: LRP130

Epitope Species: human

Product Reactivity/Detection: LRP130

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for LRP130 Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent