LRP11 Antibody (D-1): sc-514698

LRP11 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects LRP11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRP11 Antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LRP11, also known as low density lipoprotein receptor-related protein 11 or MANSC3, is a 500 amino acid single-pass type I membrane protein that plays a crucial role in lipid metabolism and cellular signaling. LRP11 is part of the LDL receptor gene family, which is characterized by a unique structure that includes a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain. These structural motifs are essential for LRP11′s function, as they facilitate interactions with various ligands and receptors, thereby influencing processes such as endocytosis and signal transduction. LRP11 is encoded by a gene located on human chromosome 6q25.1, a region associated with several diseases, including early onset intestinal cancer and Parkinson′s disease, highlighting LRP11′s importance in both normal physiology and disease states.

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LRP11 Antibody (D-1) References:

1. All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands.  |  Croy, JE., et al. 2003. Biochemistry. 42: 13049-57. PMID: 14596620
2. Low density lipoprotein receptor-related protein: regulation of the plasma membrane proteome.  |  Gonias, SL., et al. 2004. Thromb Haemost. 91: 1056-64. PMID: 15175790
3. Molecular mechanisms of lipoprotein receptor signalling.  |  May, P., et al. 2005. Cell Mol Life Sci. 62: 2325-38. PMID: 16158188
4. The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions.  |  May, P., et al. 2007. Ann Med. 39: 219-28. PMID: 17457719
5. Functional role of lipoprotein receptors in Alzheimer's disease.  |  Jaeger, S. and Pietrzik, CU. 2008. Curr Alzheimer Res. 5: 15-25. PMID: 18288927
6. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.  |  Lillis, AP., et al. 2008. Physiol Rev. 88: 887-918. PMID: 18626063
7. LRP11 activates β-catenin to induce PD-L1 expression in prostate cancer.  |  Gan, S., et al. 2020. J Drug Target. 28: 508-515. PMID: 31865764
8. LRP11-AS1 promotes the proliferation and migration of triple negative breast cancer cells via the miR-149-3p/NRP2 axis.  |  Li, P., et al. 2022. Cancer Cell Int. 22: 116. PMID: 35279146
9. LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy.  |  Sun, L., et al. 2024. J Immunother Cancer. 12: PMID: 38272565
10. LRP11-AS1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal Cancer via the miR-149-3p/CDK4 pathway.  |  Wu, Z., et al. 2025. Cancer Gene Ther. 32: 184-197. PMID: 39672916
11. LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation.  |  Liang, L., et al. 2025. Mol Med. 31: 35. PMID: 39891099
12. cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2.  |  Ishii, H., et al. 1998. Genomics. 51: 132-5. PMID: 9693042

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRP11 Antibody (D-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LRP11 Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRP11 Antibody (D-1) Specifications

Alternate Product Name: LRP11

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 29-81

Epitope Target: LRP11

Epitope Species: human

Product Reactivity/Detection: LRP11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LRP11 Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin