LRP Antibody (1032): sc-23917
- LRP Antibody (1032) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against LRP purified from MCF7 cells of human origin
- recommended for detection of LRP of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LRP Antibody (1032) for WB applications. These reagents are now offered in bundles with LRP Antibody (1032) (see ordering information below).
QUICK LINKS
SEE ALSO...
LRP Antibody (1032) is a mouse monoclonal IgG1 antibody that detects LRP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). LRP, also known as the major vault protein (MVP), plays a crucial role in mediating multidrug resistance in tumor cells, which is a significant challenge in cancer treatment. LRP is primarily located in the cytoplasm and is a key component of multimeric ribonucleoprotein complexes that transport untranslated RNA along cytoskeletal tracks, facilitating cellular processes essential for maintaining cellular homeostasis and drug transport. The presence of LRP in various multidrug-resistant cancer cell lines and clinical samples highlights its importance in understanding the mechanisms of drug resistance, as LRP overexpression can lead to reduced efficacy of anticancer therapies. LRP′s unique structure, characterized by two alternative splice variants, allows for diverse functional roles within different tissues, making LRP a vital target for research aimed at overcoming drug resistance in cancer treatment. Anti-LRP antibody (1032) is an invaluable tool for researchers investigating the complexities of drug resistance and the underlying mechanisms of LRP in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRP Antibody (1032) References:
- Expression of the major vault protein LRP in human non-small-cell lung cancer cells: activation by short-term exposure to antineoplastic drugs. | Berger, W., et al. 2000. Int J Cancer. 88: 293-300. PMID: 11004683
- Movement of vault particles visualized by GFP-tagged major vault protein. | Slesina, M., et al. 2006. Cell Tissue Res. 324: 403-10. PMID: 16505994
- Vaults and the major vault protein: novel roles in signal pathway regulation and immunity. | Berger, W., et al. 2009. Cell Mol Life Sci. 66: 43-61. PMID: 18759128
- Targeting major vault protein in senescence-associated apoptosis resistance. | Ryu, SJ. and Park, SC. 2009. Expert Opin Ther Targets. 13: 479-84. PMID: 19335069
- Inducible Major Vault Protein Plays a Pivotal Role in Double-Stranded RNA- or Virus-Induced Proinflammatory Response. | Peng, N., et al. 2016. J Immunol. 196: 2753-66. PMID: 26843330
- Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway. | Bai, H., et al. 2019. BMC Cancer. 19: 454. PMID: 31092229
- Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones. | Rayo, J., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33723037
- Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. | Loppinet, E., et al. 2023. J Am Chem Soc. 145: 18705-18710. PMID: 37590164
- Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections. | Routsias, JG., et al. 2024. Microorganisms. 12: PMID: 39338437
- The drug resistance-related protein LRP is the human major vault protein. | Scheffer, GL., et al. 1995. Nat Med. 1: 578-82. PMID: 7585126
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRP Antibody (1032) | sc-23917 | 200 µg/ml | $322.00 | |||
LRP Antibody (1032): m-IgG Fc BP-HRP Bundle | sc-536687 | 200 µg Ab; 10 µg BP | $361.00 | |||
LRP Antibody (1032): m-IgGκ BP-HRP Bundle | sc-533847 | 200 µg Ab; 40 µg BP | $361.00 | |||
LRP Antibody (1032): m-IgG1 BP-HRP Bundle | sc-544767 | 200 µg Ab; 20 µg BP | $361.00 |