LRG1 Antibody (C-5): sc-398301
- LRG1 Antibody (C-5) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 213-257 mapping within an internal region of LRG1 of mouse origin
- recommended for detection of LRG1 of mouse origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LRG1 Antibody (C-5) for WB applications. These reagents are now offered in bundles with LRG1 Antibody (C-5) (see ordering information below).
QUICK LINKS
SEE ALSO...
LRG1 Antibody (C-5) is a mouse monoclonal IgG2b antibody that detects LRG1 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRG1, or leucine-rich alpha-2-glycoprotein, is a 347 amino acid secreted protein characterized by eight leucine-rich repeats and one LRRCT domain, which play a crucial role in mediating protein-protein interactions, signal transduction, and cell adhesion. LRG1 is primarily found in plasma and is notably expressed during granulocyte differentiation, highlighting its importance in immune response and inflammation. The gene encoding LRG1 is located on human chromosome 19p13.3, a region known for housing numerous immunoglobulin superfamily members, which are vital for various immune functions. The intricate structure of LRG1, with its repeating motifs, facilitates interactions with other proteins and underscores significance in developmental processes and cellular communication. Anti-LRG1 antibody (C-5) is an essential tool for researchers investigating roles in health and disease, providing insights into function and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRG1 Antibody (C-5) References:
- LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury. | Jin, J., et al. 2019. Neuroscience. 413: 123-134. PMID: 31220542
- LRG1 Promotes Keratinocyte Migration and Wound Repair through Regulation of HIF-1α Stability. | Gao, Y., et al. 2020. J Invest Dermatol. 140: 455-464.e8. PMID: 31344385
- LRG1 promotes epithelial-mesenchymal transition of retinal pigment epithelium cells by activating NOX4. | Zhou, L., et al. 2021. Int J Ophthalmol. 14: 349-355. PMID: 33747808
- LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling. | Kwan, YP., et al. 2021. Cancers (Basel). 13: PMID: 34208965
- Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence. | Hoefsmit, EP., et al. 2023. Cancer Res Commun. 3: 672-683. PMID: 37089863
- LRG1 Is Involved in the Progression of Ovarian Cancer via Modulating FAK/AKT Signaling Pathway. | Wu, D., et al. 2023. Front Biosci (Landmark Ed). 28: 101. PMID: 37258465
- ELK4 Promotes Colorectal Cancer Progression by Activating the Neoangiogenic Factor LRG1 in a Noncanonical SP1/3-Dependent Manner. | Zhu, Z., et al. 2023. Adv Sci (Weinh). 10: e2303378. PMID: 37786278
- Association Between Plasma LRG1 and Lower Cognitive Function in Asians With Type 2 Diabetes Mellitus. | Low, S., et al. 2024. J Clin Endocrinol Metab. 109: e1732-e1740. PMID: 38170213
- Exosomal LRG1 promotes non-small cell lung cancer proliferation and metastasis by binding FN1 protein. | Wu, H., et al. 2024. Exp Cell Res. 439: 114097. PMID: 38796135
- Diet-enhanced LRG1 expression promotes insulin hypersecretion and ER stress in pancreatic beta cells. | Morales, DD., et al. 2025. Diabetologia. 68: 615-628. PMID: 39589509
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRG1 Antibody (C-5) | sc-398301 | 200 µg/ml | $322.00 | |||
LRG1 Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-538414 | 200 µg Ab; 10 µg BP | $361.00 | |||
LRG1 Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-536024 | 200 µg Ab; 40 µg BP | $361.00 |